The first World Health Organization conference on pulmonary hypertension, held in 1971 in Geneva, Switzerland [2], had been convened to investigate the first drug-induced epidemic of so-called ‘‘primary’’ pulmonary hypertension. The clinicians had noted an unusual increase in the number of patients with often fatal pre-capillary pulmonary hypertension and, by connecting the dots, they identifie...

THE behavior of the vascular bed appears to be contradictory. A number of papers indicate that the pulmonary circulation in man shows slight variations in arterial pressure during muscular exercise," after pulmonary resections" or following the occlusion of a main branch of the pulmonary artery." Conversely, other experimental and clinical studies appear to demonstrate that the pulmonary vascul...

Stenmark, Kurt R., Neil J. Davie, John T. Reeves, and Maria G. Frid. Hypoxia, leukocytes, and the pulmonary circulation. J Appl Physiol 98: 715–721, 2005; doi:10.1152/japplphysiol.00840.2004.—Data are rapidly accumulating in support of the idea that circulating monocytes and/or mononuclear fibrocytes are recruited to the pulmonary circulation of chronically hypoxic animals and that these cells ...

Although acidosis has long been known to cause vasodilation in certain systemic vascular beds (13), its effect on the pulmonary vessels remains unsettled. This uncertainty stems from the inconsistent effects of an acute change in blood pH on the pulmonary circulation of the isolated lung (4-8) and of the lung perfused in situ (9), and the lack of observations on intact animals and man. Liljestr...

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22. Luepker R, Liander BO, Korsgren M, Varnauskas E: Pulmonary intravascular and extravascular fluid volume in exercising cardiac patients. Circulation 44:626, 1971 23. Lilienfield LS, Freis EO, Partenope EA, Morowitz H: Transcapillary migration of heavy water and thiocyanate ion in the pulmonary circulation of normal subjects and patients with congestive heart failure. J Clin Invest 34:1, 1955...

Sodium 1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA/NO; Et2N-[N(O)NO]Na) is a compound that spontaneously generates nitric oxide (NO). Because of its short half-life (2.1 min), we hypothesized that inhaling DEA/NO aerosol would selectively dilate the pulmonary circulation without decreasing systemic arterial pressure. We compared the pulmonary selectivity of this new NO donor with two othe...

Background Pulmonary artery banding (PAB) is a technique of palliative surgical therapy used by congenital heart surgeons as a staged approach to operative correction of congenital heart defects. Materials and Methods We report 5- year experiences from January 2011 to January 2016 of Imam Reza Hospital center (a tertiary referral hospital in Mashhad city, North East of Iran) that consist of 50 ...

Pulmonary embolism (PE) is a common cause of morbidity and mortality in hospitalized patients. Malignancy, prolonged recumbence, and chemotherapy are renowned risk factors for development of clinically significant PE. Cancer exerts a multitude of pathophysiological processes, for example, hypercoagulability and abnormal vessels with sluggish circulation that can lead to PE. One of the peculiar ...