In the first follow up survey, we identified the set of hamlets in each village that had at least one targeted beneficiary and had not been randomly selected to be surveyed in the previous experiment; we then randomly selected one hamlet from this set. Within each hamlet, we selected 8 households to be surveyed for a total of 4,571 households. Of these 8 households, we oversampled beneficiaries...

Members of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in human cancer, but how they suppress tumorigenesis is currently unclear. Here, we use Drosophila neuroblasts to demonstrate that the SWI/SNF component Osa (ARID1) prevents tumorigenesis by ensuring correct lineage progression in stem cell lineages. We show that Osa induces a transcriptional program...

In this paper, we present a faster push-relabel algorithm for the maximum flow problem on bounded-degree networks with n vertices and m arcs. We show how to compute a maximum flow in O(mn) time. This matches the results of Orlin’s algorithm, which runs in O(mn + m log n) time on general networks (and O(mn) time on bounded-degree networks). Our main result is improving on the generic push-relabe...

The 2018 anti-government protests in Nicaragua generated a vast amount of photographic imagery, video documentation, and visual graphics. On the street via social media, everyday citizens engaged with this material, activating multisensory environment. production content was nonetheless accompanied by iconoclastic gestures; vandalism became means reclaiming Nicaragua’s revolutionary past its sy...

Recently, the anticancer activity of human α-lactalbumin made lethal to tumor cells (HAMLET) has been linked to its increased membrane affinity in vitro, at neutral pH, and ability to cause leakage relative to the inactive native bovine α-lactalbumin (BLA) protein. In this study, atomic force microscopy resolved membrane distortions and annular oligomers (AOs) produced by HAMLET when deposited ...

Some natural proteins induce tumor-selective apoptosis. α-Lactalbumin (α-LA), a milk calcium-binding protein, is converted into an antitumor form, called HAMLET/BAMLET, via partial unfolding and association with oleic acid (OA). Besides triggering multiple cell death mechanisms in tumor cells, HAMLET exhibits bactericidal activity against Streptococcus pneumoniae. The existing methods for prepa...

We used molecular approaches to study the status of speciation in coral reef fishes known as hamlets (Serranidae: Hypoplectrus). Several hamlet morphospecies coexist on Caribbean reefs, and mate assortatively with respect to their strikingly distinct colour patterns. We provide evidence that, genetically, the hamlets display characteristics common in species flocks on land and in freshwaters. S...