RATIONALE Increasing evidence indicates that alterations of the cerebral microcirculation may play a role in Alzheimer disease, the leading cause of late-life dementia. The amyloid-β peptide (Aβ), a key pathogenic factor in Alzheimer disease, induces profound alterations in neurovascular regulation through the innate immunity receptor CD36 (cluster of differentiation 36), which, in turn, activa...

The coordinated exit of intracellular pathogens from host cells is a process critical to the success and spread of an infection. While phospholipases have been shown to play important roles in bacteria host cell egress and virulence, their role in the release of intracellular eukaryotic parasites is largely unknown. We examined a malaria parasite protein with phospholipase activity and found it...

Respiratory syncytial virus (RSV), a prominent cause of airway morbidity in children, maintains an excessive hospitalization rate despite decades of research. Host factors are assumed to influence the disease severity. As a first step toward identifying the underlying resistance mechanisms, we recently showed that inbred mouse strains differ dramatically as regards their susceptibility to pneum...

Most research on employee creativity has been focused relatively distal antecedents, such as personality or job characteristics, which resulted in top-down organizational approaches to promote creativity. However, overlook the self-regulating potential of employees and may not explain intraindividual fluctuations In present research, we build proactive motivation theory examine how their own a ...

The microenvironment of the cochlea is maintained by the barrier between the systemic circulation and the fluids inside the stria vascularis. However, the mechanisms that control the permeability of the intrastrial fluid-blood barrier remain largely unknown. The barrier comprises endothelial cells connected to each other by tight junctions and an underlying basement membrane. In a recent study,...

This paper compares PVM and MPI features pointing out the situ ations where one may be favored over the other Application developers can determine where their application most likely will run and if it re quires particular features supplied by only one or the other of the APIs MPI is expected to be faster within a large multiprocessor It has many more point to point and collective communication...

This paper reviews the progress and design ideas for the new features for PVM 3.4 and describes results of our work on the longer range features that may one day be a part of the PVM system.

Santos, A. 2018. Hemodynamic Effects of Lung Function Optimization in Experimental Acute Respiratory Distress Syndrome. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1419. 60 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0210-2. Acute Respiratory Distress Syndrome (ARDS) is a severe pulmonary inflammation affecting thousands of patients eve...

The Parallel Virtual Machine (PVM), an integrated framework for heterogeneous network computing, lets scientists exploit collections of networked machines when carrying out complex scienti c computations. Under PVM, a user-de ned grouping of serial, parallel, and vector computers appears as one large distributed-memory machine. Con guring a personal parallel virtual computer involves simply lis...

High throughput methods for detecting protein interactions require assessment of their accuracy. We present two forms of computational assessment. The first method is the expression profile reliability (EPR) index. The EPR index estimates the biologically relevant fraction of protein interactions detected in a high throughput screen. It does so by comparing the RNA expression profiles for the p...