dacarbazine (dtic) is a synthetic chemical antitumor agent which is used to treat malignant melanoma and hodgkin’s disease. dtic is a prodrug which is converted to an active form undergoing demethylation by liver enzymes. the active form prevents the progress of disease via alkylation of dna strand. in the structure of this drug, the imidazole ring, a triazen chain and carboxamide group exist. ...

     Dacarbazine (DTIC) is a synthetic chemical antitumor agent which is used to treat malignant melanoma and Hodgkin’s disease. DTIC is a prodrug which is converted to an active form undergoing demethylation by liver enzymes. The active form prevents the progress of disease via alkylation of DNA strand. In the structure of this drug, the imidazole ring, a triazen chain and carboxamide group ex...

The rotating cage apparatus is used in the oil industry as a simple and effective test for corrosion. The apparatus generates a large amount of flow induced corrosion and is used by researchers to design effective corrosion inhibitors. While the apparatus is used frequently, the fluid mechanics of the problem is not well understood. Importantly, there is no correct model for the shear stress pr...

Heterocyclic compounds are of very much interest in our daily life. Heterocyclic compounds have one or more hetero atoms in their structure. They may be cyclic or non cyclic in nature. Heterocyclic compunds have a wide range of application. They are predominantly used as pharmaceuticals, as agrochemicals and as veterinary products. They also find applications as sanitizers, developers, antioxid...

The literature dealing with the electrochemical corrosion of copper and possibility of its prevention using inhibitors is examined. Inorganic compounds are investigated as well, but organic compounds and their derivatives in much greater numbers. Researches are directed to influence of compounds structure, concentration, method of application as well as media that inhibitor is used in on inhibi...

The study of the effectiveness of several potential copper corrosion inhibitors in acidic media was studied. The investigated thiazole derivative functional groups contain heterocyclic atoms such as nitrogen, sulfur, and oxygen. Thiazole derivatives, 5-benzylidene-2,4-dioxotetrahydro-1,3-thiazole (BDT) 5-(4′-isopropylbenzylidene)-2,4-dioxotetrahydro-1,3-thiazole (IPBDT), 5-(3′-thenylidene)-2,4-...

Government retains for itself, and others acting on behalf, a paid-up, nonexclusive, irrevocable worldwide license and said article to reproduce, prepare derivative works, distribute copies to the public, and perform publicly and display publicly, by or on behalf of the Government. The purposes of this project are to (1) minimize the environmental discharge of hydrocarbons and treatment chemica...

The oncogenic bHLH-LZ transcription factor Myc forms binary complexes with its binding partner Max. These and other bHLH-LZ-based protein-protein interactions (PPI) in the Myc-Max network are essential for the physiological and oncogenic activities of Myc. We have generated a genetically determined and highly specific protein-fragment complementation assay based on Renilla luciferase to analyze...

Corrosion inhibitors are added in low concentrations to corrosive solutions for reducing the corrosion rate of a metallic material. Their mechanism of action is typically the blocking of free metal surface by adsorption, thus slowing down dissolution. This work uses electrochemical impedance spectroscopy to show the cyclic oligosaccharide β-cyclodextrin (β-CD) to inhibit corrosion of zinc in 0....

objective(s):involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. materials and methods: in the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-...