نتایج جستجو برای: quantitative trait nucleotides
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Structural variants are implicated in numerous diseases andmake up themajority of varying nucleotides among human genomes.Herewedescribe an integrated set of eight structural variant classes comprising both balanced andunbalanced variants, which we constructed using short-read DNA sequencing data and statistically phased onto haplotype blocks in 26 human populations. Analysing this set, we iden...
Proteins are central to almost all cellular processes, and dysregulation of expression and function is associated with a range of disorders. A number of studies in human have recently shown that genetic factors significantly contribute gene expression variation. In contrast, very little is known about the genetic basis of variation in protein abundance in man. Here, we assayed the abundance lev...
Quantitative genetics (QG) analyses variation in traits of humans, other animals, or plants in ways that take account of the genealogical relatedness of the individuals whose traits are observed. This article focuses on "classical" QG where the analysis of variation does not involve data on measurable genetic or environmental entities or factors. Classical QG analysis employs models of genes wi...
Recent studies with the fruitfly Drosophila suggest that alleles of loci known from classical genetics can make major contributions to continuous-trait variation.
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