Sih.?Regarding Dr. Subra Row's opinion of using " quinine in pregnancy," I beg to state that in my experience "quinine" rarely does harm to a pregnant women suffering from malarial fever. Recently I treated two cases of advanced pregnancy (one seven months' pregnancy and another nine months' pregnancy), suffering from malarial fever (both with high fever, enlarged spleen and liver). I treated t...

1. " Quinine for prophylaxis will be issued in packets of 4 ozs. of quinine mixed with 1^lbs. of magnesium sulphate. This, dissolved in 1^ gallons of water, with the aid of sulphuric acid, gives a quinine content of approximately 10 grains to the ounce and is sufficient for 200 men. E. I. jugs will be provided for preparing the mixture, and a mark should be made at the 1^ gallons level." (Note....

is to be considered bad medicine, for only a "'action of these patients have malaria and need quinine. In the present shortage of quinine, such a practice is to be utterly condemned as Evolving a tragic waste of quinine. While thorough clinical examination, including ? careful history, will usually give a strong Judication whether or not the patient with lever ' has malaria, with modern methods...

Sir,?Perhaps many of yours readers are aware of the fact that adulteration of quinine was in vogue even before the war. Now that during the war its price has increased enormously, this indiscriminate adulteration is going on in a larger scale. In the mofussil one ounce of quinine, Quinine (Herrings & Co.) sells for Its. 2-8, while the same quantity of the adulterated one can be had for Rs. 1-2....

Bitter taste is one of the five basic taste sensations which is mediated by 25 bitter taste receptors (T2Rs) in humans. The mechanism of bitter taste signal transduction is not yet elucidated. The cellular processes underlying T2R desensitization including receptor internalization, trafficking and degradation are yet to be studied. Here, using a combination of molecular and pharmacological tech...

Severe immune thrombocytopenia is an idiosyncratic complication of quinine therapy. Although in most cases the responsible antibody is directed against platelet membrane glycoprotein (GP) Ib-IX, specificity for GPIIb-IIIa or both epitopes has also been reported. The objective of this study was to characterize the binding site of GPIb-IX-specific quinine-dependent antibodies. Antibody binding to...

Quinine increases the conductance of hemi-gap junctions in horizontal cells. We investigated the mechanisms of alkalinization and the hypothesis that quinine-induced alkalinization produced these conductance increases. We found that quinine-induced alkalinizations were not blocked by cobalt, amiloride, or DIDS. Therefore, this suggests that the alkalinization is not likely due to net proton flu...

(A) Flies initially prefer ethanol-containing food, but with time develop stronger preference. (B) They dislike quinine-containing food, a choice that does not change over time. (C) Initially, flies will avoid quinine-containing ethanol-food, but over time, they are willing to overcome the aversion to quinine, and will drink the alcohol-containing food. Shamsideen A. Ojelade and Adrian Rothenfluh

Quinine has become again the mainstay in treatment of multidrugresistant falciparum malaria in the eighties. During quinine treatment minor sideeffects frequently occur whereas serious side-effects such as irreversible deafness and amblyopia are rare. Using normal or low doses of quinine a syndrome termed as cinchonism is commonly observed. Mild forms consist of tinnitus, headache, nausea and v...

OBJECTIVE To summarize the existing evidence on the efficacy of artemether and arteether, two artemisinin derivatives, versus quinine for treating cerebral malaria in children. METHODS We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and the http://clinicaltrials.gov web site. We also checked the reference lists of existing systematic reviews and of all trials i...