Members of the fibroblast growth factor (FGF) family have been clinically applied to the treatment of ischemic diseases because of their strong angiogenic actions. Although tissue ischemia is predominantly caused by atherosclerosis, the roles of endothelial FGF receptors (FGF-Rs) in atherosclerosis remain obscure. We generated endothelial cell (EC)-targeted constitutively active FGF-R2-overexpr...

Despite improvements in detection, surgical approaches and systemic therapies, breast cancer remains typically incurable once distant metastases occur. High expression of TRAIL-R2 was found to be associated with poor prognostic parameters in breast cancer patients, suggesting an oncogenic function of this receptor. In the present study, we aimed to determine the impact of TRAIL-R2 on breast can...

BACKGROUND AND PURPOSE T2 hypointensity in the basal ganglia of patients with MS has been associated with clinical progression and cognitive decline. Our objectives were the following: 1) to compare signal in T2WI, R2 (ie, 1/T2), and R2* (ie, 1/T2*) relaxation rates and quantitative susceptibility mapping; and 2) to investigate the associations among MR imaging, clinical scores, and cognitive m...

Introduction: Many MRI techniques are now capable of imaging cells that have been labelled with super-paramagnetic iron oxide (SPIO) [1], and these techniques will be of great benefit to the developing field of cellular therapy. However, the majority of these techniques are not capable of providing quantitative information about cellular density at high iron concentrations, which is critical to...

Serum BTP measurement is sometimes believed to be an alternative marker of glomerular filtration rate (GFR) assessment. The aim of the present work was to investigate the correlation between creatinine, cystatin C, and BTP values in sera and to compare the diagnostic efficacy for serum BTP and cystatin C with the glomerular filtration rate estimate. 25 individuals were tested. GFR was estimated...

For the Schrödinger operator −∆ + V on R2 let N(V ) be the number of bound states. One obtains the following estimate: N(V ) ≤ 1 + ∫ R2 ∫ R2 |V (x)| |V (y)| |C1 ln |x− y|+ C2| dx dy where C1 = − 1 2π and C2 = ln 2−γ 2π (γ is the Euler constant). This estimate holds for all potentials for which the previous integral is finite.