OBJECTIVE We investigated factors related to proton pump inhibitor (PPI) -refractory gastroesophageal reflux disease (GERD) symptoms, particularly with respect to acid, the CYP2C19 genotype and psychological aspects. METHODS Patients with an Frequency Scale for the Symptoms of GERD (FSSG) score of ≥8 after the initial treatment were switched to therapy with rabeprazole at a dose of 20 mg once...

A simple and accurate methods to determine Rabeprazole sodium, in pure powder and tablet dosage form, were developed and validated using liquid chromatography (LC). The LC separation was achieved on a Inertsil ODS 3V, 150 x 4.6 mm, 5μ in the isocratic mode using buffer : acetonitrile (65 : 35, v/v), adjusted to pH 6.00 ± 0.05 with dilute KOH , as the mobile phase at a flow rate of 1.5 ml/min. t...

The aim of the present work was to develop simple, shorter and effective HPLC method with UV detection (285nm) and subsequent validation for the content uniformity determination of Rabeprazole Sodium in marketed tablet samples. The method uses isocratic mobile phase of 0.1M sodium phosphate buffer (pH adjusted to 6.5 with sodium hydroxide solution) and acetonitrile 65:35 compositions on reverse...

The objective of the current study was to develop and validate a reversed-phase high-performance liquid chromatographic method for the quantitative determination of process-related impurities and degradation products of rabeprazole sodium in pharmaceutical formulation. Chromatographic separation was achieved on the Waters Symmetry Shield RP18 (250 mm × 4.6 mm) 5 μm column with a mobile phase co...

Bilayer tablets of Domperidone (IR) Rabeprazole (SR) were formulated for the management of gastro esophageal disorder.Immediate layer of Domperidone formulated using Tulsion T-339 as super disintegrant. For sustained release of Rabeprazole HPMC as the rate controlling polymers was used. Preformulation studies were performed prior to compression. The individual layers of the bilayer tablets were...

The purpose of this study was to develop and validate a new reversed phase high performance liquid chromatographic (RP-HPLC) method to quantify in vitro dissolution assay of rabeprazole sodium in pharmaceutical tablet dosage form. Method development was performed on C 18, 100 × 4.6 mm ID, and 10  μ m particle size column, and injection volume was 20  μ L using a diode array detector (DAD) to mo...

Two simple, rapid, economical, specific, precise and accurate spectrophotometric methods have been developed for simultaneous estimation of rabeprazole sodium and domperidone maleate in their combined pharmaceutical dosage forms. Rabeprazole sodium and domperidone shows absorption maxima at 285 nm and 287 nm respectively. The first method is based on the simultaneous equations. In the simultane...

Background: Helicobacter pylori infection is a worldwide problem with more than half of the world's population in both developed and developing countries are infected this organism. The best-characterized H. adhesins, Blood group antigen binding Adhesin (BabA) Sialic acid (SabA) virulent factors which facilitate adhesion bacteria to host cells. Methods: We determined affinities selected existin...

Clopidogrel is a mainstay therapy in the cardiovascular (CVS) pharmacology for the prevention of the stent thrombosis and myocardial infarctions following many different types of coronary syndromes.The conversion of clopidogrel; which is a prodrug, to its active metabolite is mediated by the cytochrome P450 (CYP).The CYP450 metabolic activation of clopidogrel has proposed about if the competiti...

BACKGROUND Helicobacter pylori (H. pylori) treatment remains a challenge for physicians. Although highly effective, the standard sequential therapy fails in a certain number of patients. Moreover, the cure rate following a levofloxacin-amoxicillin second-line triple therapy seems to be decreasing. We tested the efficacy of modified 10-day sequential therapy, and an intensified levofloxacin-amox...