BACKGROUND The radiobiological models describe the effects of the radiation treatment on cancer and healthy cells, and the radiobiological effects are generally characterized by the tumor control probability (TCP) and normal tissue complication probability (NTCP). AIM The purpose of this study was to assess the radiobiological impact of RapidArc planning techniques for prostate cancer in term...

The radiobiological features of leukemic progenitor cells (LPC) freshly obtained from 14 T-lineage acute lymphoblastic leukemia (ALL) and 11 B-lineage ALL patients were evaluated using LPC colony assays. No significant radiobiological differences were observed between T-lineage versus B-lineage ALL LPC. Notably, the l)a values displayed a significant interpatient variation in both groups, indic...

CYRCé is a TR24 cyclotron installed at the Institut Pluridisciplinaire Hubert Curien (IPHC) of Strasbourg operating energies 16–25 MeV and intensities up to 400 ?A. The accelerator used produce provide radio-elements for PET SPECT. In 2015, IPHC started develop platform with aim performing radiobiological experiments. PRECy foresees contain three-to-five experimental stations linked beamlines e...

PURPOSE Once implanted, prostate brachytherapy seeds are vulnerable to loss and movement. A general estimation of these effects may be useful for making patient care decisions when seeds are lost after the post-implant scan. The goal of this work was to explore the dosimetric and radiobiological effects of the types of seed loss and migration common in prostate brachytherapy. METHODS This stu...

AIM OF THE STUDY Aim of the study was to compare radiobiological effects of multiple vs. single low-dose pre-irradiation on the HT29 cell line. This regime is designed to be as similar as possible to fractionated tumour radiotherapy treatment, and to provide data on radiobiological effects on human tumour cells. MATERIAL AND METHODS The cell line used in the study was HT29 (human colorectal a...

Gold nanoparticles (GNPs), have been demonstrated as effective preclinical radiosensitising agents in a range of cell models and radiation sources. These studies have also highlighted difficulty in predicted cellular radiobiological responses mediated by GNPs, based on physical assumptions alone, and therefore suggest a significant underlying biological component of response. This study aimed t...

BACKGROUND To evaluate the cytotoxic effect of carbon ion radiotherapy and chemotherapy in glioblastoma cells in vitro. METHODS AND MATERIALS The human glioblastoma (GBM) cell line U87 was irradiated with photon radiotherapy (RT) doses of 2 Gy, 4 Gy and 6 Gy. Likewise, irradiation with carbon ions was performed with single carbon doses of 0.125, 0.5, 2 and 3 Gy. Four chemotherapeutic substanc...