Radiotherapy has been the mainstay of treatment of stage III nonsmall cell lung cancer patients. In the early 90s, combined treatment with chemotherapy was introduced. In 1995, a meta-analysis showed improved treatment outcome of the sequential use of cisplatin-based chemotherapy and radiotherapy compared to radiotherapy alone. Subsequent randomized studies and two meta-analyses demonstrated th...

Adaptive radiotherapy has been introduced to manage an individual's treatment by, including patient-specific treatment variation identified and quantified during the course of radiotherapy in the treatment planning and delivering optimization. Early studies have demonstrated that this technique could significantly improve the therapeutic ratio by safely reducing the large target margin that has...

BACKGROUND AND PURPOSE To evaluate non-coplanar volumetric modulated arc radiotherapy (VMAT) trajectories for organ at risk (OAR) sparing in primary brain tumor radiotherapy. MATERIALS AND METHODS Fifteen patients were planned using coplanar VMAT and compared against non-coplanar VMAT plans for three trajectory optimization techniques. A geometric heuristic technique (GH) combined beam scorin...

Radiation therapy is one of the most commonly used treatment modalities for cancer. Its purpose is to deliver prescribed radiation doses to cancerous targets using high energy radiation beams while sparing nearby healthy organs. The treatment planning process of radiotherapy is an optimization problem, where beam parameters, such as directions, shapes, and intensities, can be adjusted in simula...

State models of piecewise-linear (PWL) autonomous dynamical systems used as prototypes in practical realizations of electronic chaotic oscillators are expressed in more generalized form that includes all previous models as special cases with the same optimum eigenvalue sensitivities. Key-Words: Dynamical systems, piecewise-linear, modeling, sensitivity optimization

We present a new fast radiotherapy planning algorithm which determines approximatively optimal gantry and table angles, kinds of wedges, leaf positions and intensities simultaneously in a global way. Other parameters are optimized only independently of each other. The algorithm uses an elaborate field management and field reduction. Beam intensities are determined via a variant of a projected N...

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RODRIGUES G. Is intensity-modulated radiotherapy for prostate cancer ready for prime-time? Can J Urol 2012;19(4):6381-6382. the therapeutic ratio between the positive anticancer effect of radiotherapy on macroscopic and microscopic disease and the negative normal tissue effects leading to both acute and late radiotherapy toxicities. In the context of prostate cancer radiotherapy, these technolo...

introduction: the selection of suitable beam angles and weights in external-beam radiotherapy is at present generally based upon the experience of the planner. therefore, automated selection of beam angles and weights in forward-planned radiotherapy will be beneficial. material and methods: in this work, an efficient method is presented within the matlab environment to investigate how to improv...

background: megavoltage beams used in radiotherapy are contaminated with secondary electrons. different parts of linac head and air above patient act as a source of this contamination. this contamination can increase damage to skin and subcutaneous tissue during radiotherapy.  monte carlo simulation is an accurate method for dose calculation in medical dosimetry and has an important role in opt...