The vast majority of patients with metastatic castration-resistant prostate cancer (mCRPC) develop bone metastases. Bone metastases are a source of significant morbidity and affect quality of life in these patients. Several bone-targeting agents are approved for the treatment of bone metastases in prostate cancer, including bisphosphonates, denosumab, and radiopharmaceuticals. Radium-223 is a n...

By Dawson F. D. Turner, M.D., F.R.C.P., Physician in Charge of Radium Department, Royal Infirmary, Edinburgh A male, aged 65, was recommended to me by Professor Alexis Thomson for radium treatment in June 1911. He was suffering from a recurrent small-celled lymphosarcoma, which was inoperable. The first operation was performed on 21st August 1909. The tumour was then situated in the axilla, and...

Large amounts of uranium, radium and radium products are redistributed throughout the environment owing to the use of phosphate fertilizers. Potential radiological impacts resulting from direct exposure, inhalation and ingestion of foods grown with fertilizers are discussed. This paper describes a simple method to measure exhalation rate of 222RN from phosphate fertilizers, clay and potatoes in...

OS Radium-223 (Xofigo, Bayer and Algeta) is a boneseeking radiopharmaceutical that patients receive via injection. It is approved by the US Food and Drug Administration (FDA) to relieve pain and prolong survival in patients with metastatic castration-resistant prostate cancer (mCRPC) who have symptomatic evidence of bone metastasis. Because radium-223 selectively targets bone, it is not indicat...

For removal of radium from saline waters in Upper Silesian mines, several methods of purification have been developed. The most efficient one is based on application of barium chloride, which was implemented in full technical scale in two Polish coal mines several years ago. Very good results of purification have been achieved-the removal efficiency exceeding 95% of the initial activity. Anothe...

Several aspects of the procedure and corrections for the calibration of encapsulated radium sources at NBS have recently been investigated. It was found that a chamber equipped with a guard-ring type electrode system allowing the use of a vibrating reed electrometer as a current detector provides more versatility and precision than the gold-leaf electroscope now in use for routine calibrations....

The study aims at measuring the gamma activity concentration (Ra, Th and K) of sub-slab filling gravel of Finnish houses. This study forms a part of a wider study aiming at exploring factors affecting high indoor radon concentrations in Finnish dwellings. The gamma activity and radon emanation were measured from gravel samples sent from 229 Finnish municipalities, the gamma activity was reporte...

E. Borgan, B. Sitter, T. F. Bathen, S. Lundgren, H. Johnsen, O. Lingjærde, T. Sørlie, A-L. Børresen-Dale, and I. S. Gribbestad Department of Genetics, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway, Department of Circulation and Imaging, NTNU, Trondheim, Norway, Deptartment of Oncology, St. Olavs University Hospital, Trondheim, Norway, Department of Informatics, Uni...

The uranium (234U/238U) and radium (228Ra/226Ra) activity ratios and 87Sr/86Sr isotopic ratio in thermal groundwater, subsurface water (groundwater) and river water from Poddebice and Uniejow were determined. The uranium and radium activity ratios and strontium isotopic ratio varied from 0.629 to 1.471, from 0.396 to 4.961 and from 0.708438 to 0.710344, respectively. The results for the thermal...

Emanation of radon ( 222 Rn) from granite countertops was measured using continuous and integrating radon monitors, and in air collected from encapsulated pieces of the countertops. A majority of the countertops emitted a measurable amount of radon. Although the granites contained the precursors, no thoron ( 220 Rn) emanation was detected. Gamma-ray spectroscopy was used to determine amounts of...