Abstract Proton beam radiotherapy (PRT) is used in the treatment of low-grade glioma (LGG) to mitigate long-term sequelae. Following PRT, increased rates radiation-induced contrast enhancements (RICE) are suspected but poorly understood. We analyzed consecutive 227 patients (42 children and 185 adults) treated with PRT (54Gy RBE) for LGG from 2010 2020 followed serial clinical exams magnetic re...

Abstract AIM Aim of the project is to report incidence moderate/severe (G ≥ 3) long-term hearing impairment (HI) and identify risk factors in patients treated for malignancies brain base skull with definitive Proton Beam Therapy (PBT) within Overseas Programme (POP). METHODS Clinical treatment-related data from patients’ files stored a national database curated by dedicated outcomes unit were e...

Abstract INTRODUCTION For elderly/frail glioma patients, shortening radiotherapy from 6 to 3 weeks (short-course RT [SC-RT]) is non-inferior standard long course (LC-RT) though usage estimated be < 20%. We analyzed real-world utilization of SC-RT with/without systemic therapy in Medicare beneficiaries treated with for primary CNS tumors using CMS data on radiation episodes. METHODS Radia...

Abstract BACKGROUND In the previous studies, intracranial germ cell tumor (iGCTs) patients with pure choriocarcinoma or mixed tumors containing components showed similar dismal prognoses median overall survival of 22 months and a one-year rate around 60%. However, those conclusions need update since radiotherapy, milestone for this disease, was not applied to many in published reports. Patients...

Abstract BACKGROUND Proton therapy (PRT) is increasingly utilized for pediatric brain tumors to reduce radiation associated treatment effects, but there a lack of data evaluating PRT in high-grade glioma (pHGG). The purpose this analysis report patterns care and clinical outcomes pHGG patients treated with enrolled the prospective Pediatric Proton/Photon Consortium Registry (PPCR). METHODS Fift...

Abstract BACKGROUND Anti-PD-1+CTLA-4 therapy has revolutionized melanoma brain metastases (MBM) treatment. Prospective trials show higher response in asymptomatic versus symptomatic patients. We evaluated clinical outcomes MBM treated with stereotactic radiosurgery (SRS) and anti-PD-1+CTLA-4. METHODS Patients were included if diagnosed SRS within 3 months of anti-PD-1+CTLA-4, this was their las...

Abstract PURPOSE Single and dual immune checkpoint inhibition (ICPI) are common treatment options for patients, particularly with melanoma non-small cell lung cancer (NSCLC). While data suggest a control benefit of combining stereotactic radiosurgery (SRS) ICPI, we hypothesized that concurrent ICPI SRS increases risk radiation necrosis (RN). METHODS We retrospectively reviewed patients metastat...

Abstract INTRODUCTION Preoperative stereotactic radiosurgery (SRS) is an emerging therapeutic strategy for treatment of brain metastasis requiring surgical resection. Prior reports have been highly-controlled, excluding very large metastases. Here, we report a prospectively-collected preoperative series reflective real-world neurosurgical patient cohort, with particular focus on resumption immu...

Abstract Meningiomas represent the most common primary brain tumor type, with a recurrence rate of approximately 20% following resection. Classification by molecular classes was demonstrated to be more accurate in identifying patients at high risk disease progression meningiomas, compared WHO grading only. Novel radiotherapeutic modalities using protons or carbon ions provide an increased relat...