The postembryonic developmental period of the nervous system involves, among other processes, an increase in the dimensions of individual neurons. In the present study we examine whether the characteristic electronic parameters that underlie the integrative properties of the neuron (L, the electrotonic length; rho, dendritic to somatic conductance ratio; and tau m, the membrane time constant) a...

Genesis of the NTP In the history of modern toxicology, few years have been more consequential than 1978—the year the National Toxicology Program (NTP) came into being. On 7 August 1978, following months of reports of serious health problems near a chemical dump site at Love Canal, New York, former President Jimmy Carter declared a federal health emergency to facilitate clean up and the relocat...

Grossmann, A. & Grossmann, G. F. (1955). J. clin. Endocrin. 15, 354. Kirk, P. L. (1950). Quantitative Ultramicroanaly8is, p. 66. New York: Wiley. Klein, E. (1954). Biochem. Z. 326, 9. Man, E. B., Smirnow, A. E., Gildea, E. F. & Peters, J. D. (1942). J. clin. Invest. 21, 773. Meyer, K. R., Dickenman, R. C., White, E. G. & Zak, B. (1955). Amer. J. clin. Path. 25, 1160. Petermann, M. L., Robbins, ...

On a cold, damp late-April day in east London, the family, friends, colleagues and admirers of muscle physiologist Roger Woledge came together to remember his life and scientific contributions at a celebratory symposium at Queen Mary University of London (QMUL). Woledge died unexpectedly in March 2015 following a riding accident, but by the end of the day-long symposium supported by The Company...

Brown, Nowakowski and Rall defined the ultimate categorical independence ratio of a graph G as A(G) = lim k→∞ i(G×k), where i(G) = α(G) |V (G)| denotes the independence ratio of a graphG, andG ×k is the kth categorical power of G. Let a(G) = max{ |U | |U |+|NG(U)| : U is an independent set of G}, where NG(U) is the neighborhood of U in G. In this paper we answer a question of Alon and Lubetzky,...

The Spheres of Influence, “Assessing Assays” (Schmidt 2002), in the May 2002 issue of EHP criticizes the National Toxicology Program rodent bioassay (NTPRB) without discussing its importance in regulation and public health. The Spheres article (Schmidt 2002) does not express concern for the validity of alternative transgenic methods proposed to replace the NTPRB for detecting carcinogens. By fo...

It is well known that sulphydryl (SH) groups are necessary for the activity of important enzyme systems. Recent work by Rall and Lehninger (1952) indicates further, that the SH groups of glutathione play a direct part in electron carriage in cellular respiration. In view of the lesions found inthe skeletal muscle in rheumatoid arthritis (Freund and others, 1945; Desmarais and others, 1948), we ...

L iving cells respond to their external environment and to signals from other cells by transducing these signals to different parts of the cell, particularly to the nucleus. This idea was initiated by RALL and SUTHERLAND [1], with the concept of cyclic adenosine monophosphate acting as a second messenger to mediate the action of the first messenger that arrived at the cell surface. Much of cell...

Rall J E, Odel H M. Congenital polycystic disease of the kidney: review of the literature and data on 207 cases. AmJ Med Sci 1949; 218: 399-407. 2 Bradford W D, Bradford J W, Porter F S, Sidbury J B, Jr. Cystic disease of liver and kidney with portal hypertension: a cause of sudden unexpected hematemesis. Clin Pediatr (Phila) 1968; 7: 299-306. 3 Parker R G F. Fibrosis of the liver as a congenit...