participation in clinical trials can be useful for the health of a person, in who it is conducted, but it does not have to be - it can even be harmful. therefore, primary motive to accept such risk is humanity and human wish to contribute to the progress of medicine; this is expressed by personal consent. the consent, however, can be an expression of personal humanity, and for this, it is not l...

Patient relevant outcomes, measured using questionnaires, are becoming increasingly popular endpoints in randomized clinical trials (RCTs). Recently, interest in the use of item response theory (IRT) to analyze the responses to such questionnaires has increased. In this paper, we used a simulation study to examine the small sample behavior of a test statistic designed to examine the difference ...

O widely accepted definition of Evidence Based Practices (EBPs) is that they are interventions for which scientific evidence consistently shows that the practice improves client outcomes.1 EBPs rely on the classifications of research studies and findings according to a variety of evidence. In general, the highest standard requires evidence from several Randomized Clinical Trials (RCTs) by multi...

clinical trial committee (ctc) has been established in food and drug organization (fdo), in 2003 to assure efficacy and safety of all types of medicinal products which are meant to be registered in iran drug list and/or obtain market authorization.all clinical trial files, meeting minutes and databases in ctc secretariat in fdo were reviewed. relevant information and data extracted, analyzed an...

stroke is an important cause of death in the world and disability world‑wide especially in developed countries. following acute phase of stroke, some procedures and medical treatment such as thrombolytic agents has been recommended; nevertheless many patients have enduring deficits. thus, there is a realistic need to develop treatment strategies for reducing neurological deficits. however, the ...

conclusions project management may benefit both the managerial and scientific aspects of medical projects and reduce fund waste. however, little has been written to date on project management in the context of clinical research. the suggestions represent the views of the individual authors. to provide a high level of evidence in this regard, we recommend that a randomized controlled trial be pe...

conclusions there is not enough evidence to support or refute the routine use of fish oil supplements during pregnancy for the prevention or treatment of diabetes. it is suggested that further randomized controlled trials be conducted to evaluate the role of fish oil supplementation in pregnancy. context one of the most common complications of pregnancy is gestational diabetes mellitus (gdm), w...