Introduction This study aimed to evaluate the TRE-induced changes in serum expression levels of miRNAs associated with lipids metabolism and autophagy process MI patients assess potential protective effects TRE these patients. Material methods post hoc investigation was performed on samples obtained from a pilot randomized, double blind, placebo-controlled clinical trial that recruited 14 men (...

Abstract Background Patients with inflammatory bowel disease (IBD) treated immunomodulators or biological therapy are at increased risk of infections. Malnutrition and vitamin mineral deficiencies common among patients IBD. The results various studies have indicate that might increase the Methods Single-centre, randomized, double-blinded, placebo-controlled clinical trial to compare a multivita...

OBJECTIVES We have reported increased 2.6-year mortality in clarithromycin- versus placebo-exposed stable coronary heart disease patients, but meta-analysis of randomized trials in coronary heart disease patients showed no significant effect of antibiotics on mortality. Here we report the 6-year mortality of clarithromycin- versus placebo-exposed patients and updated meta-analyses. METHODS Ce...

BACKGROUND Low vitamin D intake and levels have been associated with increased joint symptoms in some observational studies but the findings are mixed and evidence from randomized trials sparse. OBJECTIVE To evaluate the influence of supplemental calcium and vitamin D on joint symptoms in the Women's Health Initiative randomized, placebo-controlled, clinical trial. DESIGN In post hoc analys...

A randomized double blind cross over trial to compare nedocromil sodium and sodium cromoglycate with placebo in the prevention of exercise induced asthma was conducted. Twenty asthmatics received nedocromil sodium, sodium cromoglycate or placebo via metered dose inhalers on successive days 30 minutes before exercise in a randomized order. Nedocromil sodium and sodium cromoglycate gave sufficien...

Background: Probiotic potential (efficacy and safety) of Bacillus coagulans SNZ 1969 has been studied in patients with constipation-predominant irritable bowel syndrome (IBS-C) and-diarrhea predominant IBS (IBS-D).Methods: This randomized, double-blind, two-arm, placebo-controlled parallel study randomized 92 (1:1) to receive either 500 million CFU (treatment group) or placebo (placebo twice da...

BACKGROUND This meta-analysis of randomized controlled trials aimed to examine the advantages of long-acting injectable antipsychotics over placebo or oral medications regarding efficacy and safety for patients with bipolar disorder. METHODS Two categorical meta-analyses of randomized controlled trials were performed to compare study-defined relapse rate (primary), discontinuation rates, and ...

BACKGROUND The impact of metformin medication in pregnant women with polycystic ovary syndrome on weight gain during pregnancy and after delivery and the impact on growth of the offspring are essentially unexplored. METHODS This is a follow-up study of a randomized controlled trial (The Metformin treatment in pregnant PCOS women study), conducted in 11 secondary care centers. Women with PCOS ...

Acute myocardial infarction (MI) patients remain at high risk for recurrent events. Cholesterol efflux, mediated by apolipoprotein A-I, removes excess cholesterol from atherosclerotic plaque and transports it to the liver excretion. Impaired efflux is associated with higher cardiovascular (CV) event rates among both stable coronary artery disease recent MI. CSL112, a novel intravenous formulati...

Background Allergic rhinitis induced by house dust mites (HDMs) is a highly prevalent but often underdiagnosed and undertreated/untreated chronic disease. It has negative impact on sleep, work, leisure activities, health-related quality of life. Allergen immunotherapy proven, safe treatment for respiratory allergies. Objective We sought to assess the efficacy safety 300 index reactivity (IR) su...