BACKGROUND Patients with moderate to severe plaque psoriasis demonstrated positive responses to ixekizumab, an anti-interleukin-17A monoclonal antibody, in a phase-II, randomized, placebo-controlled trial. OBJECTIVE We sought to evaluate long-term efficacy and safety of ixekizumab. METHODS After receiving 10, 25, 75, or 150 mg of ixekizumab or placebo during randomized, placebo-controlled t...

Objectives: Nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. Numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. The aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of Nigella sativa oil in patients with rheumatoid ar...

This phase 1b/2a, randomized, double-blind, placebo-controlled, dose-escalation trial tested low-dose subcutaneous aldesleukin (recombinant IL-2) in patients with ischemic heart disease. Low-dose IL-2 expanded Tregs, without adverse events of major concern. Single-cell RNA-sequencing circulating immune cells was used to provide mechanistic assessment the treatment’s effects.

1 Swamy HS, Shankar SK, Chandra PS, et al. Neurological complications due to beta-propiolactone (BPL)-inactivated antirabies vaccination. Jf Neurol Sci 1984;63: 111-28. 2 Nichol KL, Margolis KL, Lind A, et al. Side effects associated with influenza vaccination in healthy working adults: A randomized, placebo-controlled trial. Arch Intern Med 1996;156:1546-50. 3 Govaert TM, Dinant GJ, Aretz K, e...

This letter concerns the secondary analysis (1) of Vitamin D and Type 2 Diabetes (D2d) study (2). The D2d was a randomized controlled trial to determine whether vitamin supplementation (4,000 IU per day) reduced risk diabetes among adults with prediabetes In an intention-to-treat analysis, nonsignificantly new-onset by 12% compared placebo A subsequently …

BACKGROUND Q fever is a zoonosis that is present in many countries. Q fever fatigue syndrome (QFS) is one of the most frequent sequelae after an acute Q fever infection. QFS is characterized by persistent fatigue following an acute Q fever infection, leading to substantial morbidity and a high socio-economic burden. The occurrence of QFS is well-documented, and has been described in many countr...

BACKGROUND Bright light therapy was shown to be a promising treatment for depression during pregnancy in a recent open-label study. In an extension of this work, we report findings from a double-blind placebo-controlled pilot study. METHOD Ten pregnant women with DSM-IV major depressive disorder were randomly assigned from April 2000 to January 2002 to a 5-week clinical trial with either a 70...

Title: Short-term outcomes of extracorporeal shock wave therapy for the treatment of chronic non-calcific tendinopathy of the supraspinatus: a double-blind, randomized, placebo-controlled trial.

Judd LL, Rapaport MH, Yonkers KA, et al. Randomized, placebo-controlled trial of fluoxetine for acute treatment of minor depressive disorder. Am J Psychiatry 2004;161:1864–71. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

Correction: Short-term efficacy of rofecoxib and diclofenac in acute shoulder pain: A placebo-controlled randomized trial. PLoS Clin Trials 2(5): e24.