We have compared the size and shape of ferritins from human heart, rat heart, and skeletal muscle with those of rat liver and horse spleen ferritins, using sedimentation and gel filtration techniques. The electrophoretically "fast" form of heart ferritin was partially separated from both the "slow" heart form and from rat liver ferritin by gel filtration (Stokes radii 72 A versus 69 and 68.5 A)...

We report here that the rat heart is a site of oxytocin (OT) synthesis and release. Oxytocin was detected in all four chambers of the heart. The highest OT concentration was in the right atrium (2128 +/- 114 pg/mg protein), which was 19-fold higher than in rat uterus but 3.3-fold lower than in the hypothalamus. OT concentrations were significantly greater in the right and left atria than in the...

The repeated administration of methamphetamine (MAP) causes behavioral sensitization in animals. We previously reported that the high accumulation of MAP was observed in the MAP-sensitized animal brain, which suggested that this phenomenon is an important factor in the development or expression of behavioral sensitization. The purpose of the present study is to elucidate the MAP distribution in...

reports have shown the antioxidant, hypotensive, hypolipidemic and vasodilatory effects of grape (vitis vinifera l.) seed extract. we have recently shown the relaxatory effect of grape leaf extract on rat uterus and reduction of frog heart rate and contractility. the aim of the present study was to investigate the relaxant effect of vitis vinifera leaf hydroalcoholic extract (vlhe) on rat thora...

introduction: the effect of regular exercise in decreasing the incidence of heart diseases is well known. the abuse of anabolic androgenic steroids (aas) has been associated with cardiovascular disorders. uncoupling proteins (ucps) transport protons across the inner mitochondrial membrane thereby proton gradient can be diminished by the action of ucps. this process will result in the uncoupling...

Parallel incubations with uniformly 14C-labeled oleic and elaidic acids were conducted to compare oxidation rates in tissue homogenates prepared from rat and human hearts. Radioactivity in 14CO2 and 14C-labeled chain-shortened acid-soluble products was used to measure the extent of oxidation. Oxidation rates (pmol/min per mg heart protein) determined on 14C-labeled acid-soluble products suggest...

background: methyl 2-benzimidazole carbamate (carbendazim) is a synthetic fungicide used against organisms that cause different types of plant diseases. it is widely used as a preservative in leather, paint, textile, fruit, and paper industry. it is also used as an anticancer drug in clinical medicine. methods: to evaluate the low dose toxicity of this compound in mammalian tissues, carbendazim...