1. Colony-stimulating activity appeared in the perfusate of the isolated rat liver during perfusions with either whole rat blood, rat plasma or an artificial perfusate of Eagle's medium and albumin. 2. Dialysable inhibitors of colony formation were also released during perfusions. 3. Colony-stimulating activity in artificial perfusate could be enhanced by the addition of rat plasma in vitro. Co...

androsten-17a-yl)propionic acid g-lactone (SPN), is a competitive aldosterone antagonist, which is used as a potassiumsparing diuretic in premature infants to reduce lung congestion. The stability of SPN in solution was reported by Pramar and Gupta. In the study, SPN was most stable at pH 4.5, and the degradation rate increased with increasing and decreasing pH. The apparent first-order rate co...

The transgenic rat TGR(mRen-2)27, in which the Ren-2 mouse renin gene is transfected into the genome of the rat, develops severe hypertension with high adrenal renin and low kidney renin. These animals express both mouse and rat renin. To investigate the cause of hypertension in the TGR rat, we compared the kinetics of mouse renin acting on mouse and rat angiotensinogens. The optimum pH of the ...