Rate-distortion optimization (RDO) plays an essential role in substantially enhancing the coding efficiency. Currently, rate-distortion optimized mode decision is widely used in scalable video coding (SVC). Among all the possible coding modes, it aims to select the one which has the best trade-off between bitrate and compression distortion. Specifically, this tradeoff is tuned through the choic...

BACKGROUND Imaging studies have revealed widespread neurodegeneration in Parkinson's disease (PD), but only a few considered the issue of asymmetrical clinical presentations. OBJECTIVE To investigate if the side of onset influences the pattern of gray matter (GM) atrophy in PD. METHODS Sixty patients (57.87 ± 10.27 years) diagnosed with idiopathic PD according to the U.K. Brain Bank criteri...

Defects in the dystrophin gene cause the severe degenerative muscle disorder, Duchenne muscular dystrophy (DMD). Among the gene therapy approaches to DMD under investigation, a gene editing approach using oligonucleotide vectors has yielded encouraging results. Here, we extend our studies of gene editing with self-pairing, chimeric RNA/DNA oligonucleotides (RDOs) to the use of oligodeoxynucleot...

This paper shows the application of reliability methods in the content of robust design optimization. Several reliability methods are presented and discussed. The consequences of the proper treatment of stochastic uncertainties are demonstrated with the aid of a simple structural example. As a result it is seen that the suggested reliability methods help to define safety factors to compensate f...

We have analyzed two variants of Drosophila melanogaster (RS and RE) which lead to the dual phenotype of elevated DDC activity and increased resistance to dietary alpha-methyldopa relative to Oregon-R controls. Both phenotypes show tight genetic linkage to the dopa decarboxylase, Ddc, and l(2)amd genes (i.e., < 0.05 cM distant). We find that low (Oregon-R), medium (RS) and high (RE and Canton-S...

Abslracl-In this a er we ex lore controllabilit in Wpping R ht for Micro Aeri8&hides (dAVs), inch-size rdo t s ca able oFautonomous Rght Differently from previous work, we focus on a MAV with very limited wmg kinematics and simple input control schemes. In particular, in the first part we show how an MAV provided with a pair of wings, each with a single de ree of freedom and assive rotation, ca...

HEVC doubles the coding efficiency with more than 4x coding complexity as compared to H.264/AVC. To alleviate the burden of Intra encoder, we estimate the RD-cost from the source image textures, and dynamically select two promising CU/PU mode candidates to execute exhaustive RDO processing. As integrated in our hardwired encoder, the averaged 61.7% computation complexity was saved with 4.53% ra...

Tradeoff between different resources (bitrate, computational time, etc.) and compression quality, often referred to as rate-distortion optimization (RDO), is a key problem in video coding. With a little exaggeration, it can be claimed that what distinguishes between a good and a bad codec is how optimally it finds such a tradeoff. This is the first part of our paper presenting an algorithm for ...

This paper presents an efficient mode decision scheme for down-sizing video transcoding in H.264 using support vector machines (SVMs). In order to reduce the high computational complexity of using conventional mode decision in the H.264 re-encoder, the proposed scheme uses SVMs to exploit the correlation between coding information extracted from the input high-resolution bit-stream and the codi...