A major cause of male infertility, which includes 50 causes of infertility, is oxidative stress.  The aerobic respiration in the sperm cell is associated with the production of reactive oxygen species (ROS). Some reactions such as sperm capacitation and acrosome reactions require moderate levels of ROS. However, when the amount of ROS production surpasses the natural antioxidant defense of the ...

This review will focus on the role of reactive oxygen species in the cellular and tissue effects of low level light therapy (LLLT). Coincidentally with the increase in electron transport and in ATP, there has also been observed by intracellular fluorescent probes and electron spin resonance an increase in intracellular reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, singlet...

spermatozoa generate reactive oxygen species (ros) in physiological amounts which play a role in sperm functions during sperm capacitation acrosome reaction (ar) and oocyte fusion. in addition damaged sperm are likely to be the source of ros. the most important ros produced by human sperm are hydrogen peroxide superoxide anion and hydroxyl radicals. besides human seminal plasma and sperm posses...

mycophenolic acid (mpa) is the active metabolite of mycophenolate mofetil. this study designed to investigate the mechanism of cytotoxicity of mpa on the genetically engineered pc12 tet off (pto) neuronal cells with p53 gene. alamar blue (ab) reduction showed concentration-dependent cytotoxicity of mpa on pto cells with ic50 value of 32.32 ± 4.61 mm. the reactive oxygen species (ros) generation...

All aerobic organisms use molecular oxygen as terminal oxidant during respiration. Oxygen is neither very reactive nor harmful, but it has the potential to be only partially reduced, leading to the formation of very reactive and therefore toxic intermediates, like singlet oxygen (1O2), superoxide radical (O2·-), hydroperoxylradical (HO2·-), hydrogen peroxide (H2O2) and hydroxylradical (·OH). Th...

Mesoporous Materials In article number 2208316, Xiaohui Ju and co-workers report the design of free-blockage reactive oxygen species (ROS)-responsive mesoporous silica nanoparticles (MSNs) as potential drug delivery systems. Methyl sulfide units are functionalized onto MSNs through co-condensation or grafting pathways. an ROS-rich environment, nanocarriers undergo structure polarity changes rel...

Oxidative DNA damage (ODD) by reactive oxygen species (ROS) or nitrogen (RNS) is an inevitable tradeoff for using oxidation processes living cells as a source of energy [...]

Many years of research have seen the investigation natural antioxidants and dietary supplements as functional foods with potential to prevent oxidative stress due scavenging reactive oxygen species (ROS) nitrogen (RNS) [...]

We assessed the generation of reactive oxygen species (ROS: O2-, H2O2, OH . , chemiluminescence) by neutrophils and monocytes from six patients with infectious mononucleosis, ten patients with other viral diseases, and ten normal controls. Neutrophils from infectious mononucleosis patients showed markedly decreased generation of all reactive oxygen species, compared with the two control groups;...

seizure activity has been proposed to result in the generation of reactive oxygen species (ros), which then contribute to seizure-induced neuronal damage and eventually cell death. although the mechanisms of seizure-induced ros generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. we aim to determine the sources of seizure-induced ros and ...