نتایج جستجو برای: receptor targeting

تعداد نتایج: 717575  

Journal: :Cell 2001
Ulla-Maija Koivisto Ann L. Hubbard Ira Mellman

Basolateral targeting of membrane proteins in polarized epithelial cells typically requires cytoplasmic domain sorting signals. In the familial hypercholesterolemia (FH)-Turku LDL receptor allele, a mutation of glycine 823 residue affects the signal required for basolateral targeting in MDCK cells. We show that the mutant receptor is mistargeted to the apical surface in both MDCK and hepatic ep...

Journal: :Medicinal Chemistry Research 2021

Gonadotropin-releasing hormone (GnRH) analogs (e.g., triptorelin) are developed to treat hormone-dependent reproductive cancers. However, these lack a significant direct antitumor activity make them suitable for hormone-refractory In this study, we examined different biological properties of lipid-modified GnRH analogs, with/without D-amino acid substitution at position 6 in prostate and ovaria...

Journal: :Trends in immunotherapy 2023

The angiotensin-converting enzyme 2 (ACE2) receptor gained prominence in 2020, having been identified as a prime for entry of the novel coronavirus COVID-19, which has led to current global pandemic. Many studies have reported that lung cancer patients higher risk contracting COVID-19 due up-regulated expression ACE2 cells. Lung is heterogeneous disease and most frequently occurring globally. I...

Journal: :Journal of cell science 2015
Adi Bercovich-Kinori Eitan Bibi

The signal recognition particle (SRP) receptor is a major player in the pathway of membrane protein biogenesis in all organisms. The receptor functions as a membrane-bound entity but very little is known about its targeting to the membrane. Here, we demonstrate in vivo that the Escherichia coli SRP receptor targets the membrane co-translationally. This requires emergence from the ribosome of th...

AbstractPyrimidine nucleosides are constituents of fundamental structure of the cells. There has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensi...

2017
Rui Li Ke Zheng Cai Yuan Zhuo Chen Mingdong Huang

Malignant tumor (cancer) remains as one of the deadliest diseases throughout the world, despite its overall mortality drops. Nanomaterials (NMs) have been widely studied as diagnostic and/or therapeutic agents for tumors. A feature of NMs, compared to small molecules, is that NMs can be concentrated passively in tumors through enhanced permeability and retention (EPR) effect. In the meantime, N...

David Greyson

The role of the nuclear medicine has changed, from the early days when it was the only alternative to x-rays, to the present, when nuclear images are interpreted in light of specific metabolic processes, not anatomy. The development of specific receptor targeting radiopharmaceuticals, markers of viability using PETor SPECT, analogues of neurotransmitters etc., have placed the nuclear medi...

Journal: :American journal of physiology. Cell physiology 2002
Sarah F Hamm-Alvarez

On binding to its receptor, epidermal growth factor (EGF) initiates a cascade of events leading to cell proliferation or differentiation. In addition, the EGF receptor itself is downregulated to attenuate mitogenic signaling. Downregulation occurs through trafficking of receptors to lysosomes, culminating in proteolytic destruction of both the receptor and ligand; however, endocytic sorting mec...

Journal: :Current opinion in pharmacology 2008
Michael Pollak

The family of insulin/insulin-like growth factor (IGF) receptors regulates many crucial aspects of cellular and whole-organism physiology. Evidence that targeting these receptors may be useful in cancer treatment was first recognized more than 20 years ago. Drug development began relatively recently, justified both by laboratory studies and by circumstantial clinical evidence that this receptor...

Journal: :iranian journal of pharmaceutical research 0
akbar mobinikhaledi arak university- org. chem naser foroughifar azad university/arak university tahere mosleh arak university ahmad hamta arak university/biology dept

abstractpyrimidine nucleosides are constituents of fundamental structure of the cells. there has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensi...

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