BACKGROUND We have recently shown that serum relaxin-2 levels are attenuated in women with a history of recurrent pregnancy loss (RPL). We sought to determine whether a history of RPL is also associated with changes in serum matrix metalloproteases (MMPs) and tissue inhibitors of matrix metalloproteases (TIMP) -1 and -2. METHODS We obtained serum from 20 pregnant women with a history of RPL a...

Transforming growth factor β1 plays a significant role in pregnancy outcome. We investigated the association of TGFB1 exon 1 (rs1800471, rs1800470) and promoter region (rs1800469, rs1800468) polymorphisms with recurrent pregnancy loss (RPL) in 675 Tunisian women: 304 women with a history of three consecutive pregnancy losses of unknown etiology with the same partner and 371 age-matched multipar...

Recurrent pregnancy loss (RPL) is estimated to occur in 2.5% of women trying conceive. Definition RPL varies depending on used guideline. In Europe, defined as two or more lost pregnancies before 24 weeks’ gestation. Although many factors have been associated with a higher risk recurrent miscarriage, the aetiology unknown about half cases. Several related loss, such as: environmental, behaviora...

BACKGROUND Immune-mediated recurrent pregnancy loss (RPL) has received more attention than any other single etiologic classification. Individuals with rare blood group P have an antipp1pk antibody in their serum, which causes recurrent abortion in the early stages. MATERIALS AND METHODS In this case series study, 11 patients with unexplained RPL who had anti-P antibody in their serum were tre...

conclusions: we determined a significant higher frequency of protein s deficiency in patients with rpl compared with controls. but the frequency of protein c deficiency and the frequency of two common thrombophilic mutations (factor v leiden and prothrombin g20210a), were not significantly different between patients with recurrent miscarriage and healthy women. results: the mean functional acti...

Early pregnancy loss in a wanted is stressful and frustrating to any couple. It becomes even more emotionally traumatic when it occurs repeatedly. Two or of early known as recurrent (RPL). RPL clinical challenge for physicians unriddle. In this case report, we illustrate 40-year-old woman who experienced six first-trimester losses. After the third loss, initial maternal blood investigations wer...

The subsequent reproductive outcomes in couples with a history of recurrent pregnancy loss (RPL) associated with chromosome abnormalities or polymorphisms are generally not reported in China. Many RPL carrier couples have decided not to have children. The present study recorded the subsequent delivery, miscarriage, and unpregnancy outcomes of 113 RPL carrier couples and 226 non-carrier couples,...

Background: Recurrent pregnancy loss (RPL) is a multifactorial problem associated with genetic abnormalities reflected by inherited disorders. The aim of the present study was to investigate the contribution of heterochromatin polymorphism in couples with recurrent miscarriages compared with couples without miscarriages. Materials and Methods: Over a 3 year period, we made a study of the diagno...

BACKGROUND Recurrent pregnancy loss (RPL) is a multifactorial disorder. Environmental factors and genetics can affect pregnancy outcomes. OBJECTIVE Conflicting data suggest an association between estrogen receptor alpha (ESR1) gene polymorphisms and RPL. In this study, such association was investigated in Iranian women with RPL. MATERIALS AND METHODS In this case control study, blood sample...