Background: Mild cognitive impairment (MCI) is a common non-motor symptom of early Parkinson’s disease (PD), but the neural mechanisms underlying it remain poorly understood. The aim of the present study was to investigate the characteristics of cognition-related brain activities in the PD patients with MCI. Methods: The brain fMRIs and cognition tests were acquired in 39 PD patients and 22 hea...

UNLABELLED Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Previous fMRI studies investigating PBD were mainly task-related. However, little is known about the abnormalities in PBD, especially during resting state. Resting state brain activity measured by fMRI might help to explore...

Several brain regions and connectivity networks may be altered as aging occurs. We are interested in investigating if resting-state functional magnetic resonance imaging (RS-fMRI) can also be valid as an indicator of individual differences in association with inhibition performance among aged (including middle-aged) people. Seventy-two healthy adults (40-77 years of age) were recruited. Their R...

Purpose: Presbycusis, age-related hearing loss, is believed to involve neural changes in the central nervous system, which is associated with an increased risk of cognitive impairment. The goal of this study was to determine if presbycusis disrupted spontaneous neural activity in specific brain areas involved in auditory processing, attention and cognitive function using resting-state functiona...

Tics in Gilles de la Tourette syndrome (GTS) resemble fragments of normal motor behaviour but appear in an intrusive, repetitive and context-inappropriate manner. Although tics can be voluntarily inhibited on demand, the neural correlates of this process remain unclear. 14 GTS adults without relevant comorbidities participated in this study. First, tic severity and voluntary tic inhibitory capa...

Low frequency oscillations are essential in cognitive function impairment in schizophrenia. While functional connectivity can reveal the synchronization between distant brain regions, the regional abnormalities in task-independent baseline brain activity are less clear, especially in specific frequency bands. Here, we used a regional homogeneity (ReHo) method combined with resting-state functio...

The early detection of major depression in elderly individuals who are at risk of developing the disease is of prime importance when it comes to the prevention of geriatric depression. We used resting-state functional magnetic resonance imaging (fMRI) to examine changes in regional homogeneity (ReHo) of spontaneous activity in late-life subthreshold depression (StD), and we evaluated the sensit...

The Behavioral Inhibition System (BIS) as defined within the Reinforcement Sensitivity Theory (RST) modulates reactions to stimuli indicating aversive events. Gray's trait Anxiety determines the extent to which stimuli activate the BIS. While studies have identified the amygdala-septo-hippocampal circuit as the key-neural substrate of this system in recent years and measures of resting-state dy...

Abstract Background Although several brain networks play important roles in cervical dystonia (CD) patients, regional homogeneity (ReHo) changes CD patients have not been clarified. We investigated to explore ReHo at rest and analyzed its correlations with symptom severity as measured by Tsui scale. Methods A total of 19 21 gender-, age-, education-matched healthy controls underwent fMRI scans ...

The task induced blood oxygenation level dependent signal changes observed using functional magnetic resonance imaging (fMRI) are critically dependent on the relationship between neuronal activity and hemodynamic response. Therefore, understanding the nature of neurovascular coupling is important when interpreting fMRI signal changes evoked via task. In this study, we used regional homogeneity ...