نتایج جستجو برای: reinforcing efficacy
تعداد نتایج: 317146 فیلتر نتایج به سال:
background & aim: skin-to-skin contact immediately after birth plays a pivotal role in proper breastfeeding and mother-infant interaction. despite numerous benefits of mother-infant skin-to-skin contact, this health behavior is not performed by many midwives. this study aimed to evaluate the influential factors for mother-infant skin-to-skin contact based on the precede-proceed model from the p...
Collective behaviors often spread via the self-reinforcing dynamics of critical mass. In collective behaviors with strongly self-reinforcing dynamics, incentives to participate increase with the number of participants, such that incentives are highest when the full population has adopted the behavior. By contrast, when collective behaviors have weakly self-reinforcing dynamics, incentives to pa...
Efficacy estimation of erythropoiesis-stimulating agents using erythropoietin-deficient anemic mice.
We devised a high-throughput chemoproteomics method that enabled multiplexed screening of 16,000 compounds against native protein and lipid kinases in cell extracts. Optimization of one chemical series resulted in CZC24832, which is to our knowledge the first selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with efficacy in in vitro and in vivo models of inflammation. Extensive target...
The governmenT launched a national campaign last week to remind healthcare professionals about the problem of antibiotic resistance, and to make clear to patients that antibiotics will not cure the common cold (Department of health, 2008a). resistance to antibiotics is still increasing, and action is necessary to preserve the efficacy of existing antibiotics. As many patients visit gPs complain...
Probiotics are viable by definition, and viability of probiotics is often considered to be a prerequisite for the health benefits. Indeed, the overwhelming majority of clinical studies in the field have been performed with viable probiotics. However, it has also been speculated that some of the mechanisms behind the probiotic health effects may not be dependent on the viability of the cells and...
Are initial competitive advantages self-reinforcing, so that markets exhibit an endogenous tendency to be dominated by only a few firms? Although this question is of great economic importance, no systematic empirical study has yet addressed it. Therefore, we examine experimentally whether firms with an initial cost advantage are more likely to invest in cost reductions than firms with higher in...
The present study assessed the efficacy of the cannabinoid CB1 receptor antagonist, SR-141716, in reducing voluntary ethanol intake in selectively bred Sardinian alcohol-preferring (sP) rats. Ethanol (10%, v/v) and food were available in daily 4 h scheduled access periods; water was present 24 h/day. The acute administration of a 2.5 and a 5 mg/kg dose of SR-141716 selectively reduced ethanol i...
Epidermal growth factor receptor (EGFR)-targeted tyrosine kinase inhibitors (TKIs) have emerged as first-line drugs for non-small cell lung cancers (NSCLCs). However, the resistance to TKIs represents the key limitation for their therapeutic efficacy. We found that miR-26a was upregulated in gefitinib-refractory NSCLCs; miR-26a is downstream of EGFR signaling and directly targets and silences p...
PURPOSE The purpose of this study was to identify the effects of mothers' involvement in a dental health program for their elementary school children. METHODS This study was a non-equivalent control group pre-post test design in which knowledge and behaviors related to dental health, perceived benefits and barriers, self-efficacy and plaque control scores were compared between the experimenta...
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