modern leukemia and lymphoma sequencing standards, is an improvement in signal-to-noise ratio for Hodgkin lymphoma given the incredible rarity of the Reed-Sternberg cell in its background nest of inflammatory infiltrate. Previous studies relying on laser capture microdissection could also increase the signal-to-noise ratio, but at the cost of time, effort, and still-low cell numbers. This work ...

Autologous stem cell transplant remains the standard of care for relapsed Hodgkin lymphoma (HL). Approximately 50% of patients with chemo-sensitive relapse will be cured with this approach. The optimal pretransplant salvage regimen is controversial, but less toxic combinations seem to be equivalent to more aggressive approaches. For patients with chemo-refractory disease at relapse and those fa...

background epstein-barr virus (ebv) is a dna virus which belongs to the herpesviridae family and in γ-herpesvirus subfamily, has been infected about 95% of the world’s population. ebv is transmitted through saliva and associated with different disease such as infectious mononucleosis, nasopharyngeal carcinoma, burkitt`s lymphoma, hodgkin and non-hodgkin`s lymphoma. the study proposed to determi...

This study examines the activity and tolerability of a regimen combining vorinostat and rituximab in patients with indolent B-cell non-Hodgkin lymphoma. A total of 28 patients with newly diagnosed or relapsed/refractory follicular, marginal zone, or mantle cell lymphoma, with 4 or less prior therapies were eligible for this open-label phase II study. Oral vorinostat 200 mg was administered twic...

  Primary non-Hodgkin lymphoma of the larynx is rare, accounting for less than 1% of all laryngeal neoplasms. Fewer than 100 cases have been reported in the literatureand to our knowledge this may be the first reported case of laryngeal non Hodgkin lymphoma presented with hoarseness, aortic aneurysm, hepatitis B and skin rashes.

background and objectives: human herpes 6 virus (hhv-6) could remain latent and chronic in the host cells after primary infection. hhv-6 genome encodes certain trans activation proteins which may results in development of malignantlymphoma. the association of human herpes six virus (hhv-6) infection and hodgkin and non-hodgkin lymphomas is strongly supported by epidemiological studies. the aim ...

lymphomas are solid malignant tumors having a wide spectrum of clinical and pathological features. non-hodgkin’s lymphoma (nhl) is a subtype of lymphoma with two-thirds of the cases presenting as lymph node enlargement. the remaining one third of nhl cases has been reported in the extranodal sites, including the gastro intestinal tract, waldeyer’s ring, bone, skin, and brain. intraoral non-hodg...

BACKGROUND B-cell lymphoma comprises the majority of non-Hodgkin lymphomas worldwide. Hematopoietic cell transplantation (HCT) is used for patients with high-risk, relapsed, or refractory B-cell lymphoma. METHODS The current medical literature and the results of recently published trials were reviewed to provide an update on the most common indications for HCT in B-cell lymphoma. RESULTS Au...