نتایج جستجو برای: related macular degeneration amd
تعداد نتایج: 1225783 فیلتر نتایج به سال:
OBJECTIVE To determine whether vitamin E supplementation influences the incidence or rate of progression of age related maculopathy (AMD). DESIGN Prospective randomised placebo controlled clinical trial. SETTING An urban study centre in a residential area supervised by university research staff. PARTICIPANTS 1193 healthy volunteers aged between 55 and 80 years; 73% completed the trial on ...
PURPOSE To evaluate the relationship between retinal vascular caliber (RVC), iris color, and age-related macular degeneration (AMD) in elderly Irish nuns. METHODS Data from 1233 participants in the cross-sectional observational Irish Nun Eye Study were assessed from digital photographs with a standardized protocol using computer-assisted software. Macular images were graded according to the m...
PURPOSE. The degeneration of retinal pigment epithelial (RPE) cells is considered to be a crucial event in the pathophysiology of age-related macular degeneration (AMD). Cumulative oxidative damage has been implicated in the development of the changes seen in AMD. The present study was undertaken to evaluate the expression of the small heat shock protein Bcrystallin in the RPE in response to ox...
Age-related macular degeneration (AMD) is a major cause of vision loss. It is associated with development of characteristic plaque-like deposits (soft drusen) in Bruch's membrane basal to the retinal pigment epithelium (RPE). A sequence variant (Y402H) in short consensus repeat domain 7 (SCR7) of complement factor H (CFH) is associated with risk for "dry" AMD. We asked whether the eye-targeting...
OBJECTIVE To describe characteristics of the Age-Related Eye Disease Study (AREDS) 9-step severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial (CAPT). METHODS Eligibility criteria for CAPT required 10 or more large (>or=125 microm) drusen in each eye. Readers graded baseline photographs from all participants and all follow-up photogr...
Age-related macular degeneration (AMD) is one of the main socioeconomical health issues worldwide. AMD has a multifactorial etiology with a variety of risk factors. Smoking is the most important modifiable risk factor for AMD development and progression. The present review summarizes the epidemiological studies evaluating the association between smoking and AMD, the mechanisms through which smo...
Neurodegenerative diseases affecting the macula constitute a major cause of incurable vision loss and exhibit considerable clinical and genetic heterogeneity, from early-onset monogenic disease to multifactorial late-onset age-related macular degeneration (AMD). As part of our continued efforts to define genetic causes of macular degeneration, we performed whole exome sequencing in four individ...
Age-related macular degeneration (AMD) is a potentially blinding disease that can be treated by verteporfin photodynamic therapy. This article discusses the specialist ophthalmic nurse's role in the assessment, treatment and support of patients with AMD, highlighting key elements in the care pathway and the benefit of prompt triage in safeguarding remaining vision.
PURPOSE To study different aspects of macular function in eyes with early age-related macular degeneration (early AMD: drusen with or without retinal pigment epithelium alterations) and normal visual acuity, to obtain a complete evaluation of macular function impairment in early AMD and to study the relationship between macular function and the ophthalmoscopic signs of early AMD. METHODS Fort...
Citation: Qiu F, Matlock G, Chen Q, et al. Therapeutic effects of PPARa agonist on ocular neovascularization in models recapitulating neovascular agerelated macular degeneration. Invest Ophthalmol Vis Sci. 2017;58:5065– 5075. DOI:10.1167/iovs.17-22091 PURPOSE. This study was designed to evaluate effects of fenofibric acid (Feno-FA), a peroxisome proliferator–activated receptor-alpha (PPARa) ago...
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