Protein kinase C (PKC) plays an important role in the cell signal transduction of many physiological processes. In contrast to these physiological responses, increases in PKC activity have also been associated with inflammatory disease states, including ulcerative colitis. The objective of this study was to examine the role of PKC as a causative mediator in initiation of experimentally induced ...

Background Small children with dilated vesicoureteral reflux (VUR) run risk of recurrent urinary tract infections (UTI) and to acquire renal damage. To protect them, antibiotic prophylaxis and surgery to eliminate VUR have been used. Endoscopic injection of bulking agent at the ureteral orifice has evolved as alternative surgical method but with insufficient scientific support of long term effe...

BACKGROUND AND AIM: Since increasing the proportion of elderly in the world, so oral lesions related to removable denture-wearing are an important issue. The aim of this study was to evaluate the prevalence of denture-related oral mucosal lesions (DMLs) in removable denture wearers referred to clinics of Kerman, Iran.METHODS: This cross-sectional study was conducted on 350 removable denture wea...

Early childhood growth retardation persists in developing countries despite decades of nutritional interventions. Adequate food is necessary, but not sufficient, to ensure normal growth where there is ubiquitous exposure to infection. Pathways associated with infection, small intestinal mucosal damage and chronic immunostimulation remain largely undemonstrated in countries other than The Gambia...

OBJECTIVE To investigate the role of endothelin on nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX2) enzyme inhibitors-induced effects on the gastric mucosa. METHODS This study was carried out in the Department of Pharmacology Laboratory, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey during the period January to December 2002. In the first group ...

Neutrophil adherence within the gastric microcirculation is thought to be a major step in the pathogenesis of gastric mucosal damage induced by indomethacin. Pentoxifylline, a methylxanthine derivative, prevents leukocyte adherence to vascular endothelium and protects organs from shock by reducing tumour necrosis factor alpha (TNF alpha) concentrations. Rats were treated with 20 mg/kg oral indo...

The plasticity region of Helicobacter pylori is a large chromosomal segment including isolate-specific open reading frames with characteristics of pathogenicity islands. It remains unclear whether genes in the plasticity region play a role in the pathogenesis of gastric mucosal inflammation and gastroduodenal disease. Our aim was to assess the role of selected genes in the plasticity region in ...

involvement in intestinal function is carried through two " Collateral Damage " in the other chapters in disparate areas of interest. One describes the role of cytokines in the IgA response, to Nervous System which much of the mucosal response is dedicated. N. Lycke presents a conceptually pleasing and logically In Defense of the Brain: Current Concepts in the Im-formatted discussion of the for...

Recent studies have suggested that dietary fiber exerts a therapeutic effect on inflammatory bowel disease patients. The aim of this study was to evaluate the effects of a dietary fiber, germinated barley foodstuff (GBF), derived from the aleurone and scutellum fraction of germinated barley against dextran sulfate sodium (DSS)-induced experimental colitis in rats. Sprague-Dawley rats were fed a...