The causes of Stevens-Johnson syndrome (SJS) can be categorized as iatrogenic, infectious or idiopathic. Drug-induced SJS is associated with various antibiotics, anticonvulsants, and other drugs. However, no previous reports have mentioned an association between chlordiazepoxide, a benzodiazepine sedative, and SJS. Here, we present a case of SJS induced by chlordiazepoxide overdose. This case r...

Longitudinal studies of the determinants of children's health are complex, costly, infrequent, and incredibly valuable. It has become clear in recent years that the periconceptional environment plays a surprisingly large role in the health of the resulting child. This short introduction to this mini-monograph briefly recaps the articles included herein and reminds us that adequate forethought a...

An investment strategist recently published, in the journal Nature, an impassioned plea to all scientists that they must begin to speak out on the resource crisis exacerbated by global warming. In this Editorial response, the author reminds health professionals that they can no longer stay silent and pander to the ignorance of others, and challenges them, along with multidisciplinary partners a...

Identifying and accessing all pulp canals is particularly challenging in the endodontic treatment of teeth with atypical canal configurations. This report describes the nonsurgical endodontic treatment of a maxillary first premolar with three root canals. The prevalence of this unusual morphology is reviewed and suggestions are offered to help dentists identify and treat such teeth. This case r...

This paper describes a context aware pervasive calm medication reminder system. The system aims at improving the anticoagulant treated patient’s medication adherence based on context awareness. By using advanced sensor technology to register the user context, the system reminds the patient to take the medication timely. The system prototype was tested and evaluated by a patient, and was reporte...

Gallstone ectopia in the lungs is relatively rare, which accounts for its frequent misdiagnosis. This paper reports a case found in a suspicious lung cancer surgery. The patient received intrahepatic duct stone removal surgery and partial hepatectomy five months prior to the report. He started showing symptoms of cough and hemoptysis without any apparent cause one month before this report. Enha...

Decades of research has shown that long-term changes in synaptic function ultimately require changes in gene expression.Recent work has focused on nuclear signaling by calcium and protein messengers initiated at postsynaptic sites. In this issue of The EMBO Journal, Ivanova and colleagues show that shuttling of CtBP-1 between presynaptic areas and nuclei regulates gene expression, which reminds...

1. “LAUDATO SI’, mi’ Signore” – “Praise be to you, my Lord”. In the words of this beautiful canticle, Saint Francis of Assisi reminds us that our common home is like a sister with whom we share our life and a beautiful mother who opens her arms to embrace us. “Praise be to you, my Lord, through our Sister, Mother Earth, who sustains and governs us, and who produces various fruit with coloured f...

Houses in tHe woods Residential growth pressures have arrived at the edge of Maine's North Woods. Kathleen Bell in this article examines changes in the economics of rural land use in Maine. She notes that public debate over Plum Creek's proposal for development in the Moosehead region reminds us that we need to increase our understanding of the interactions between residential growth pressures,...

Editors’ Note: To celebrate Presence’s 25th year of publication, we have invited selected members of the journal’s original editorial board and authors of several early articles to contribute essays looking back on the field of virtual reality, from its very earliest days to the current time. This essay comes from founding editorial board member Mike Zyda, who highlights similarities between ye...