Experiments were performed in mice to investigate whether cyclooxygenase-2 (COX-2) in epithelial cells near the tubulovascular contact point (macula densa and TAL cells) may regulate renin gene expression in juxtaglomerular granular cells. Renin activity, afferent arteriolar granularity, and renin mRNA were determined in wild-type mice and in COX-2-knockout mice on control and low-NaCl diets. R...

The activities of brain renin and cathepsin D were measured in brain regions of 10 dogs on a normal sodium intake (65 mEq Na/day) and 10 other dogs placed on a low sodium diet (< 4 mEq Na/day) for 21 days and given a diuretic. The purpose of this study was twofold: to assess the effect of sodium depletion on brain renin activity; and to assess in the same regions alterations in brain renin and ...

The activities of brain renin and cathepsin D were measured in brain regions of 10 dogs on a normal sodium intake (65 mEq Na+/day) and 10 other dogs placed on a low sodium diet (less than 4 mEq Na+/day) for 21 days and given a diuretic. The purpose of this study was twofold: to assess the effect of sodium depletion on brain renin activity; and to assess in the same regions alterations in brain ...

Royal jelly (RJ) is known to possess several physiological and pharmacological properties. A dipeptide YY derived from RJ proteins is known to inhibit angiotensin converting enzyme (ACE) activity. Our previous study showed that the dipeptide YY inhibited the human renin activity at physiological pH. In this study, we investigated the pH dependency of the inhibitory effect of the dipeptide YY to...

The effect of a 3-h Sidman avoidance operant conditioning schedule (liver pressing to avoid an electric shock) on plasma renin activity and renin substrate concentration was examined in baboons (Papio cynocephalus). Plasma samples were drawn over a 24-h period on both the control and test days, and the avoidance session was presented on the morning of the test day. Plasma renin activity was sig...

Spontaneously hypertensive Okamoto-strain rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were actively immunized with mouse renin to investigate the effect on blood pressure of blocking the renin-angiotensinogen reaction. Ten male SHR and 10 male WKY rats were immunized with purified mouse submandibular gland renin. Control rats were immunized with bovine serum albumin. Antirenin antibodie...

1. Strains of spontaneously hypertensive and normotensive rats were selected by repeated inbreeding. 2. Brief ether anesthesia was shown to produce a two- to three-fold increase in plasma renin activity in both strains. 3. Plasma renin activity was significantly higher in young spontaneously hypertensive than in normotensive rats of the same age (5-7 weeks). After the ninth week plasma renin ac...

r‘ MALVIN, RICHARD L., AND ARTHUR J. VANDER. Plasma renin activity in marine teleosts and Cetacea. Am. J. Physiol. 2 13 (6) : 1582-l 584. 1967.-Renin activity was measured in the plasma of two species of tuna and one species of a euryhaline fish (Tilapia mossambica) which was adapted to fresh water for varying periods of time. In addition renin activities were also measured in five species of C...

MEYER, PHILIPPE, JOEL MENARD, NIC~LAS PAPANICOLAOU, JEAN-M. ALEXANDRE$LAUDINE DEVAUX,AND PAUL MILLIEZ. Mechanism of renin release following furosemide diuresis in rabbit. Am. J. Physiol. 215(4) : 908-915. 1968.-Injection of furosemide (10 mg/kg, iv) into rabbits increased plasma renin activity within 7 min; plasma renin activity increased further throughout the course of the experiment and rvas...

Serial determinations of plasma renin activity, sodium balance, urinary potassium excretion rate, and plasma sodium and potassium concentration were done in five dogs during dietary-induced potassium depletion and repletion. Duration of depletion for the different animals ranged from 5 to 7 wk. Plasma renin activity increased in all animals during depletion, with rises being demonstrated as ear...