نتایج جستجو برای: replication kinetic
تعداد نتایج: 188066 فیلتر نتایج به سال:
Cancer, as one of the most serious public health problems, is the second-leading cause of death in the world after cardiovascular disease. The number of patients and the resulting mortality are increasing worldwide; therefore, early diagnosis, prevention, and effective treatment of cancer are very important. Current treatments such as chemotherapy and radiation therapy are often non-selective a...
Due to the asymmetric nature of the nucleotides, the extant informational biomolecule, DNA, is constrained to replicate unidirectionally on a template. As a product of molecular evolution that sought to maximize replicative potential, DNA's unidirectional replication poses a mystery since symmetric bidirectional self-replicators obviously would replicate faster than unidirectional self-replicat...
Kinetic models using enzyme kinetics are developed for the three ways that Louie proved that Rosen’s minimal (M-R)-System can be closed to efficient cause; i.e., how the ‘‘replication’’ component can itself be entailed from within the system. The kinetic models are developed using the techniques of network thermodynamics. As a demonstration, each model is simulated using a SPICE circuit simulat...
Enzymes have the remarkable ability to select the correct substrate from the pool of chemically similar molecules. The accuracy of such a selection is determined by differences in the free-energy profiles for the right and wrong reaction pathways. Here, we investigate which features of the free-energy landscape govern the variation and minimization of selectivity error. It is generally believed...
Polymerases are protein enzymes that move along nucleic acid chains and catalyze template-‐based polymerization reactions during gene transcription and replication. The polymerases also substantially improve transcription or replication fidelity through the non-‐equilibrium enzymatic ...
V iroids and viruses can be viewed as ultimate parasites, which exploit the host through entering cells and manipulating cellular metabolism for their own reproduction. Proliferation of viruses is bound to successful replication of virus genomes, RNA or DNA, where successful implies viable virus progeny, that is, capable of reproduction. Viroids are naked RNA molecules and therefore entirely de...
HIV replication requires nuclear export of unspliced and singly spliced viral transcripts. Although a unique RNA structure has been proposed for the Rev-response element (RRE) responsible for viral mRNA export, how it recruits multiple HIV Rev proteins to form an export complex has been unclear. We show here that initial binding of Rev to the RRE triggers RNA tertiary structural changes, enabli...
As grow as the data-intensive applications in cloud computing day after day, data popularity in this environment becomes critical and important. Hence to improve data availability and efficient accesses to popular data, replication algorithms are now widely used in distributed systems. However, most of them only replicate the static number of replicas on some requested chosen sites and it is ob...
In eukaryotic cells, Flap endonuclease 1 (FEN1) is a major structure-specific endonuclease that processes 5' flapped structures during maturation of lagging strand DNA synthesis, long patch base excision repair, and rescue of stalled replication forks. Here we report that fanconi anemia complementation group A protein (FANCA), a protein that recognizes 5' flap structures and is involved in DNA ...
Hepatitis C virus (HCV) infection is a major global health burden and is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. There remains an unmet medical need for efficacious and safe direct antivirals with complementary modes of action for combination in treatment regimens to deliver a high cure rate with a short duration of treatment for HCV patients. Here we ...
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