.............................................................................................................................. ii Acknowledgements ............................................................................................................. iii Foreword............................................................................................................................. iv...

On September 21-23, 1981, a workshop was held in Rockville, MD, to discuss specific issues related to the evaluation of data for risk assessment in reproductive toxicology (including teratology). The workshop was sponsored by the Interagency Regulatory Liaison Group (IRLG) and was organized by the IRLG Reproductive Toxicity Risk Assessment Task Group.t The Task Group's original charge was to de...

Reproductive health problem is more common nowadays and various causes like nutritional defect, socio-economic problems, life style changes are reason for that, among those reason, one important factor is environmental factor. In this study, the pesticide, Lindane is used to induce reproductive toxicity and the levels of male reproductive hormone, antioxidant and histopathology of rat testis wa...

Arsenic is a toxic metalloid that exists ubiquitously in the environment, and affects global health problems due to its carcinogenicity. In most populations, the main source of arsenic exposure is the drinking water. In drinking water, chronic exposure to arsenic is associated with increased risks of various cancers including those of skin, lung, bladder, and liver, as well as numerous other no...

A special challenge in the new European Union chemicals legislation, Registration, Evaluation and Authorisation of Chemicals, will be the toxicological evaluation of chemicals for reproductive toxicity. Use of valid quantitative structure-activity relationships (QSARs) is a possibility under the new legislation. This article focuses on a screening exercise by use of our own and commercial QSAR ...

2,4-Dichlorophenoxyacetic acid (2,4-D) was assessed for systemic toxicity, reproductive toxicity, developmental neurotoxicity (DNT), developmental immunotoxicity (DIT), and endocrine toxicity. CD rats (27/sex/dose) were exposed to 0, 100, 300, 600 (female), or 800 (male) ppm 2,4-D in diet. Nonlinear toxicokinetic behavior was shown at high doses; the renal clearance saturation threshold for 2,4...