BACKGROUND In vitro studies have indicated that epidermal growth factor receptor (EGFR) may intensify signaling output by the receptor's overexpression, heterodimerization with HER-2, or autocrine expression of ligands. The purpose of the present study was to evaluate the correlation between EGFR and its related proteins and to explore the prognostic value of the proteins. MATERIALS AND METHO...

OBJECTIVE In this study, we aimed to evaluate the efficacy of pegylated interferon alpha 2a and adefovir dipivoxil treatment in chronic hepatitis B patients. METHODS This study was performed on patients treated for chronic hepatitis B in the Infectious Disease Clinic of Eskişehir Osmangazi University between 01.09.2005 and 31.03.2008. A total of 30 patients aged between 18 and 65 years consti...

Plant cell wall degradation by Clostridium cellulovorans requires the cooperative activity of its cellulases and hemicellulases. To characterize the alpha-L-arabinosidases that are involved in hemicellulose degradation, we screened the C. cellulovorans genomic library for clones with alpha-L-arabinofuranosidase or alpha-L-arabinopyranosidase activity, and two clones utilizing different substrat...

PURPOSE To determine the effect of tyrosine-phosphorylated signal transducer and activator of transcription 3 (pSTAT3) immunoexpression on survival in two independent cohorts of patients with squamous cell carcinoma of the head and neck (SCCHN) and to evaluate pSTAT3, transforming growth factor-alpha (TGF-alpha), epidermal growth factor receptor (EGFR), and gastrin-releasing peptide receptor (G...

Nonsensitized human and mouse lymphocytes produce interferon (IFN)-alpha and IFN-alpha/beta, respectively, in response to most transformed cells, as well as normal xenogeneic cells. The treatment of transformed human (WISH) and mouse (L) or normal mouse embryo (ME) cells with trypsin, pepsin, or neuraminidase resulted in a loss of the cell's ability to induce IFN-alpha or alpha/beta. These find...

The specific involvement of G proteins in thrombin receptor-mediated Ca2+ mobilization and DNA synthesis has been studied in single Chinese hamster lung fibroblasts (CCL39 cells) activated by the hexapeptide SFLLRN. Immunoblots performed with antibodies directed against the COOH terminus of G protein alpha subunits revealed that alpha q, alpha i, and alpha o were each present in CCL39 cells. Th...

Introduction: The aim of the present study was to determine the levels of alpha particles and heavy metals contamination in the meat products consumed in Najaf, Iraq. Moreover, this study was also targeted toward comparing the results with those in the literature and making appropriate conclusion and recommendations. Material and Methods: This study determined the track of alpha particles and ...

purpose the present study investigated the psychometric properties of a malaysian adapted brunel mood scale. methods the questionnaire was administered to 355 young sport athletes with a mean age of 14.69+1.70 years. confirmatory factor analysis (cfa) and cronbach's alpha were used to determine the factorial validity and the internal consistency of the questionnaire respectively. results cfa re...