OBJECTIVE We used lumbar magnetic resonance image (MRI) findings to determine possible outcome predictors of a caudal epidural steroid injection (CESI) for radicular pain caused by a herniated lumbar disc (HLD). METHODS Ninety-one patients with radicular pain whose MRI indicated a HLD were enrolled between September 2010 and July 2013. The CESIs were performed using ultrasound (US). A respond...

unresponsiveness to hepatitis b surface antigen (hbsag) has been shown to be associated with dysfunction of the presenting cells (apc) and defect in the specific b-lymphocyte and/or t-lymphocyte repertoires.   direct determination of the frequency of specific t-lymphocytes together with complementary analysis of the naive circulating immune cells could provide valuable information about the cel...

BACKGROUND This study evaluated a specialized whey fraction (Prolibratrade mark, high in leucine, bioactive peptides and milk calcium) for use as a dietary supplement to enhance weight loss. METHODS This was a randomized, double-blind, parallel-arm, 12-week study. Caloric intake was reduced 500 calories per day. Subjects consumed Prolibra or an isocaloric ready-to-mix beverage 20 minutes befo...

UNLABELLED Omalizumab is an anti-IgE monoclonal antibody available since 2006 for the treatment of GINA step 4 asthma. We studied a 41-year old male who has been suffering from severe steroid-resistant asthma with severe co-morbidity and treated with Omalizumab. He was found to be non-responder to the treatment until the 48th week, starting from which we began to see a distinct improvement in t...

For some years there has been intense interest in the problem of cellular expression of immune response (Ir) 1 genes. Initial experiments suggested that T cells alone were responsible for Ir manifestations since, for example, mice which were low responders to poly-L-(Tyr,Glu)-poly-D,L-Ala--poly L-Lys [(TG)-A--L] could make antibodies to this antigen coupled to methylated bovine serum albumin (1...

We studied the genetic restrictions on the interaction between T cells, B cells, and antigen-presenting cells (APC) involved in the H-2-linked Ir gene control of the in vitro secondary antibody response to sperm whale myoglobin (Mb) in mice. The B cells in this study were specific for Mb itself, rather than for a hapten unrelated to the Ir gene control, as in many previous studies. Low responde...

OBJECTIVE The objectives of this study were to evaluate the performance and safety of an innovative passive light photon driven microscopic biomodulator patch as an alternative medical device for tinnitus relief. MATERIALS AND METHODS Eighty-two (82) patients were randomized to receive either an active (biomodulator) patch or a placebo patch, for a 3-week treatment period. Patch performance (...

Based on pressing need for predictive performance improvement, we explored the value of pretherapy tumour histology image analysis to predict chemotherapy response. It was shown that multifractal analysis of breast tumour tissue prior to chemotherapy indeed has the capacity to distinguish between histological images of the different chemotherapy responder groups with accuracies of 91.4% for pPR...

Erythrocytes from the same mouse strains gave similar results; here the cell number was increased to 109/ml to obtain a significant difference between curves for highand low-responder mice. It is possible that these results are affected by contamination with mouse ferritin from the spleen or plasma despite washing of cells. To minimize possible contamination by mouse ferritin, lymph-node cells,...

Abstract The Glioblastoma (GB) field has been experiencing a therapeutic standstill since 2005, primarily due to ineffective preclinical approaches test anti-cancer treatments. Therefore, better treatment screening are required. We developed NADH FLIM-based functional precision medicine approach, that within one week after surgery identified two groups of TMZ Responder and Non-Responder tumors....