RENAL hypertension caused by cellophane wrapping was reported by Oster and Martinez to be associated with polydipsia and polyuria. Braun-Menendez found that hypertensive rats with one normal and one perinephritic kidney showed a rise in water intake and output; in bilateral perinephritis these changes were exaggerated and were associated with decreased renal clearances and nitrogen retention. S...

A LTHOUGH excessive retention of sodium and water is a striking feature in frank congestive heart failure, little is known about the abnormalities in body fluid and electrolyte metabolism in cardiac patients with severe heart disease prior to the development of obvious peripheral edema. Previous studies in nonedematous cardiac patients have not revealed any impairment in the handling of oral or...