PURPOSE To report an image segmentation algorithm that was developed to provide quantitative thickness measurement of six retinal layers in optical coherence tomography (OCT) images. DESIGN Prospective cross-sectional study. METHODS Imaging was performed with time- and spectral-domain OCT instruments in 15 and 10 normal healthy subjects, respectively. A dedicated software algorithm was deve...

PURPOSE To determine the relationship between optical coherence tomography (OCT) images of the retina and retinal substructure in vitro and in vivo. METHODS In vitro, OCT images of human and bovine retina were acquired after sequential excimer laser ablation of the inner retinal layers. Measurements of bands in the OCT images were compared with measurements of retinal layers on histology of t...

In the last decade retinal diseases have become prevalently in India and it is growing alarmingly. Fortunately, most of blindness are caused are preventable if treated at appropriate time. Early detection of such retinal diseases like diabetic retinopathy, macular degeneration, retinal detachment and glaucoma is very vital. Optical coherence tomography (OCT) is an In vivo imaging technique for ...

PURPOSE To determine the presence of structural changes in HIV retinae (i.e., photoreceptor density and retinal thickness in the macula) compared with age-matched HIV-negative controls. METHODS Cohort of patients with known HIV under CART (combination Antiretroviral Therapy) treatment were examined with a flood-illuminated retinal AO camera to assess the cone photoreceptor mosaic and spectral...

SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness maps. Forty-three patients with various retinal pathologies and 113 normal subj...

During early vertebrate eye development, a regulatory network of transcription factors regulates retinal cell differentiation and survival into adulthood. Among those factors, Krüppel-like factor 4 (KLF4) plays the dual role of maintaining the stem cell status of retinal progenitors cells and repressing the intrinsic axon regeneration ability in retinal ganglion cells (RGCs) after injury. This ...

PURPOSE To investigate the correlation of outer retinal layers (ORL) thickness and visual acuity (VA) in patients with diabetic macular edema (DME). METHODS Consecutive DME patients seen at the Retina Clinic of The University of Hong Kong were recruited for OCT assessment. The ORL thickness was defined as the distance between external limiting membrane (ELM) and retinal pigment epithelium (RP...

During early vertebrate eye development, a regulatory network of transcription factors regulates retinal cell differentiation and survival into adulthood. Among those factors, Krüppel-like factor 4 (KLF4) plays the dual role of maintaining the stem cell status of retinal progenitors cells and repressing the intrinsic axon regeneration ability in retinal ganglion cells (RGCs) after injury. This ...

background:  optical coherence tomography (oct) is a non-invasive instrument, which can be used to estimate the thickness of the retinal nerve fibre layer (rnfl) and provides an indirect measurement of axonal destruction in multiple sclerosis (ms). the main aim of this study was to find out any correlations between p100 latency in visual evoked potential (vep) and rnfl thickness. methods: the p...

PURPOSE To identify the factors which significantly contribute to the thickness variabilities in macular retinal layers measured by optical coherence tomography with or without magnification correction of analytical areas in normal subjects. METHODS The thickness of retinal layers {retinal nerve fiber layer (RNFL), ganglion cell layer plus inner plexiform layer (GCLIPL), RNFL plus GCLIPL (gan...