Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease that can affect any part of the human body including the eyes. Common blinding ocular manifestations include central retinal artery occlusion (CRAO), central retinal vein occlusion (CRVO), severe vaso-occlusive retinopathy, and optic nerve involvement. Antiphospholipid syndrome (APS) in lupus is usually associated ...

Clinical trials in patients with macular edema due to diabetic retinopathy or retinal vein occlusion (RVO) have shown that suppression of VEGF not only improves macular edema, but also reopens closed retinal vessels, prevents progression of vessel closure, and improves retinopathy. In this study, we show the molecular basis for those clinical observations. Increased retinal levels of VEGF in mi...

In branch retinal vein occlusion (BRVO), abnormal arteriovenous crossing with vein compression, degenerative changes of the vessel wall and abnormal hematological factors constitute the primary mechanism of vessel occlusion. In general, BRVO has a good prognosis: 50-60% of eyes are reported to have a final visual acuity (VA) of 20/40 or better even without treatment. One important prognostic fa...

PURPOSE Recent studies suggest that the cannulation of retinal vessels may provide a potential access route for the administration of thrombolytic agents in retinal vessel occlusion. However, the major problem with available techniques is the limited visualization of retinal vessels with conventional surgical microscopes, making it difficult to effectively control the targeted injection of drug...

Direct laser treatment of retinal neovascularisation is indicated when regression has not been brought about by retinal photocoagulation. Current treatment regimens involve multiple laser applications to the neovascular complex. Long-duration low-energy burns have the advantage of slowly heating the tissue without engendering disruption. We report the use of this treatment as a means of occludi...

Neovascular glaucoma is a secondary glaucoma with grave prognosis which follows ischemic retinal disorders in the majority of cases. Mediators that induce new vessel formation such as the vascular endothelial growth factor-A seem to play a key role in the pathophysiology of this condition. Herein, we report 2 cases with neovascular glaucoma secondary to ischemic central retinal vein occlusion w...

The HRP/trypsin technique is a new histologic method for the light microscopic study of the retinal blood vessels. A two-stage procedure, the first step results in a retinal whole amount preparation which permits visualization of the three-dimensional architecture of perfused vessels and their relationship within the retina. This allows analysis of gross vessel morphology and differentiation of...

We analyzed the vascular densities (VDs) of optic disc areas in eyes with normal-tension glaucoma (NTG) according to their branch retinal vessel occlusion (BRVO) status. The VDs discs and peripapillary 68 NTG patients BRVO (BRVO group; fellow eyes) 37 alone (control were measured on angiographic images obtained via swept-source optical coherence tomography angiography. compared among groups cor...

to investigate the effect of preprocessing techniques including contrast enhancement and illumination correction on retinal imagequality, a comparative study was carried out. we studied and implemented a few illumination correction and contrast enhancementtechniques on color retinal images to find out the best technique for optimum image enhancement. to compare and choose thebest illumination c...

detecting blood vessels is an important task in retinal image analysis.  the task is more challenging with the presence of bright and dark lesions in retinal images. here, a method is proposed to detect vessels in both normal and abnormal retinal fundus images based on their linear features. first, the negative impact of bright lesions is reduced by using k-means segmentation in a perceptive sp...