To assess whether retinoblastoma formation is associated with the expression of high mobility group (HMG) A2 protein, a transcription factor that is highly expressed during embryogenesis and completely repressed in normal adult tissues, we performed Northern and Western blots and RT-PCR analyses, and immunohistochemistry to test for HMGA2 expression. We used established retinoblastoma cell line...

Objective: To assess the rationale for bone marrow biopsy/aspiration as a part of routine systemic workup in advanced intraocular retinoblastoma (RB) relation to high-risk histopathological post-enucleation features. Methods: A retrospective observational study was conducted at Department Pediatric Hematology and Oncology Children’s Hospital, Lahore, Pakistan. Data regarding demographics, clini...

PURPOSE In mice, genetic changes that inactivate the retinoblastoma tumor suppressor pathway often result in pancreatic neuroendocrine tumors (Pan-NETs). Conversely, in humans with this disease, mutations in genes of the retinoblastoma pathway have rarely been detected, even in genome-wide sequencing studies. In this study, we took a closer look at the role of the retinoblastoma pathway in huma...

Trefoil factor family (TFF) peptides have been shown to effect cell proliferation, apoptosis, migration and invasion of normal cells and various cancer cell lines. In the literature TFF peptides are controversially discussed as tumor suppressors and potential tumor progression factors. In the study presented, we investigated the effect of TFF3 overexpression on growth, viability, migration and ...

To generate animal models of retinoblastoma that closely resemble metastatic and nonmetastatic human disease for the purposes of examining tumor biology and of developing alternate treatments, human retinoblastoma cell lines were injected into the vitreal cavities of immunodeficient mice. Two reproducible animal models with contrasting biologic behavior analogous to human retinoblastoma have be...

Trilateral retinoblastoma is a rare, but well recognized syndrome. These tumors usually occur in the pineal, parasellar, or suprasellar regions several years after successful management of ocular retinoblastomas without evidence of direct extension or distant metastasis. Here we report a case of trilateral retinoblastoma presenting initially with a sellar tumor and with concurrent unilateral re...

Diffuse anterior retinoblastoma is a rare variant of retinoblastoma seeding in the area of the vitreous base and anterior chamber. Patients with diffuse anterior retinoblastoma are older than those with the classical types, with the mean age being 6.1 years. The original cells of diffuse anterior retinoblastoma are supposed to be cone precursor. Patients most commonly present with pseudouveitis...

Ocular Oncology Service, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India Email: [email protected] Abstract : Retinoblastoma is the most common malignant intraocular tumor of childhood, with an incidence of 1 in 16,000 to 18,000 live births. The most common symptoms of retinoblastoma are leukocoria and strabismus. The diagnosis of retinoblastoma is delayed in the developing countr...

Retinoblastoma is extremely rare in adults. We report a case of Retinoblastoma diagnosed by histopathology in an enucleated specimen of a 37 year old patient who presented with pain and diminished visual acuity with intraocular mass and serous detachment. CT head and orbit showed uniform hyperdense mass in nasal quadrant of left globe projecting into adjacent vitreous cavity. Chest X Ray and US...

Background In 2003, we reported an increased risk of retinoblastoma in children conceived by in vitro fertilization (IVF) between 1995 to 2002. However, population-based studies among children conceived by IVF did not find an elevated risk of retinoblastoma. Methods From nationwide estimates of numbers of live births conceived by IVF (n = 40,330), we estimated the expected numbers of retinoblas...