All-trans-retinoic (atRA) acid is a biologically active derivative of vitamin A that regulates numerous physiological processes through its interaction with nuclear retinoid receptor proteins, termed as retinoid acid receptors (RARs) and retinoid X receptors (RXR). Retinoid signaling is diverse and its role in embryonic development, adult growth and development, maintenance of immunity and epit...

A particular system of brain mechanisms, called the retinoid system, is proposed as the evolutionary adaptation responsible for the existence of subjectivity and our sense of being here in a surrounding 3D world. The structural and dynamic properties of the retinoid system successfully predict a novel conscious experience in which the brain constructs a vivid visual representation of an object ...

Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-type zinc-finger motif. RINF expression correlates with retinoid-induced differ...

Recent advances in developmental nephrology have provided new evidence that retinoids, vitamin A and its active metabolites such as all-trans retinoic acid, profoundly influence renal organogenesis. Retinoids are acknowledged as potent nephron mass regulators. They regulate embryonic kidney patterning through control of Ret expression in a dose-dependent manner, which modulates ureteric bud bra...

In HEK293S cells expressing opsin, rhodopsin regenerates on addition of all-trans retinol. This study was to determine if key proteins in the retinal pigment epithelium (RPE) are present in these cells. Cellular retinoid binding protein, cellular retinoic-acid binding protein, RPE65, caveolin-1-alpha- and -beta-isoforms, interphotoreceptor retinoid binding protein, and 11-cis retinol dehydrogen...