Therapeutic cancer vaccines (or active immunotherapy) aim to guide the patient's personal immune system to eradicate cancer cells. An exciting approach to cancer vaccines has been offered by nanoscale drug delivery systems containing tumor associated antigens (TAAs). Their capacity to stimulate the immune system has been suggested during late years. However, the role of the macrophages as key-e...

An important task of the scientific community is to provide non-specialized audience with explanations about what is nanoscience. Such explanations can be given during public conferences, seminars in high schools or lab work organized with teachers. And very often, the use of an experimental illustration greatly helps to raise the interest and the curiosity of the public. The present article wi...

The aim of this study was to investigate the feasibility of using layer-by-layer polymer coated gold nanoparticles (AuNP) as a carrier for topical iontophoretic delivery of imatinib mesylate (IM). AuNP were prepared by the Turkevich method and were stabilized and functionalized using polyvinylpyrrolidone and polyethylene imine. The functionalized AuNP were then sequentially coated with anionic ...

a high performance liquid chromatography method was studied for determination of 18 ?-glycyrrhetinic acid in glycyrrhiza glabra l. (licorice) extract. the operating condition were c-18 reversed phase column (vp-ods, (250×4.6 mm, 5 mm)) at room temperature, acetonitril/phosphoric acid (3/1) as mobile phase, at flow rate of 0.6ml/min (0-8min), 0.4ml/min (8-20min) and uv detection at 230 nm. the r...

Chromatography, although primarily a separation technique, is mostly employed in chemical analysis in which High-performance liquid chromatography (HPLC) is an extremely versatile technique where analytes are separated by passage through a column packed with micrometer-sized particles. Now a day reversed-phase chromatography is the most commonly used separation technique in HPLC. The reasons fo...

a simple and sensitive high performance liquid chromatographic method with electrochemical detection is described for the quantitative determination of the amoxycillin and clavulanic acid in pharmaceutical dosage forms. separation of sample components occurs on a reversed phase c18 column with a mobile phase consisting of methanol-water-phosphate buffer. for the amperometric detection, the pote...

iv ACKNOWLEDGMENTS I would like to thank my advisor Dr. Lili He for her full support and encouragement throughout my research. The experience I gained and opportunities I had in this lab greatly exceeded my expectations, for which I am grateful. I would also like to thank Dr. Decker and Dr. Zhang for being members on my committee and for their input on my thesis. I would finally like to thank D...