Objective(s):Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. One of the hallmarks of AD is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. In this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in AD and tauopathies. Unfortunately, the available syntheti...

Kinetics of sarcomere movement were studied in real-time by laser diffraction. Instantaneous sarcomere shortening was measured during afterloaded twitches simultaneously with instantaneous shortening and tension of the whole trabecula excised from rat right ventricle. Resting sarcomere length at optimal length was 2.20 +/- 0.02 micron (mean +/- SEM). Maximum amplitude of sarcomere shortening wa...

Diastolic function is a major determinant of ventricular performance, especially when loading conditions are altered. We evaluated biventricular diastolic function in lambs and studied possible load dependence of diastolic parameters [minimum first derivative of pressure vs. time (dP/dt(min)) and time constant of isovolumic relaxation (tau)] in normal (n = 5) and chronic right ventricular (RV) ...

Precision measurements of the anomalous electromagnetic moment leptons ( a l ) may serve as one most promising directions in search for new physics beyond Standard Model. While experimental value electron magnetic agrees with theoretical predictions up to 11 significant digits, muon shows deviations from Model at level 4.2 sigma, indicating possible occurrence effects. Although τ tau lepton its...

We propose a Clifford algebra based model, which treats both gravity and YangMills interactions as gauge fields. There are two sectors of boson fields as electroweak and Majorana bosons. The electroweak boson sector induces fermion masses via spontaneous symmetry breaking. It is composed of scalar Higgs, pseudoscalar Higgs, and antisymmetric tensor components. The Majorana boson sector contribu...

Experimental measurements collected by the BABAR, Belle, and LHCb experiments on different observables associated with semileptonic transition $b \to c \tau \bar{\nu}_\tau$, indicate existence of disagreement respect Standard Model predictions. We analyse charged scalar boson contributions to these charged-current $B$ meson anomalies within framework two Higgs doublet model most general Yukawa ...

However, this changes the interpretation of our results but slightly, because exact probability distribution metric is only important for choice and stopping criterium clustering.

In this paper the periodic solutions of fourth order delay differential equation of the form $ddddot{x}(t)+adddot{x}(t)+f(ddot{x}(t-tau(t)))+g(dot{x}(t-tau(t)))+h({x}(t-tau(t)))=p(t)$  is investigated. Some new positive periodic criteria are given.  

Illumination of crayfish giant axons, during internal perfusion with 0.5 mM methylene blue (MB), produces photodynamic effects that include (i) reduction in total sodium conductance, (ii) shifting of the steady-state inactivation curve to the right along the voltage axis, (iii) reduction in the effective valence of steady-state inactivation and, (iv) potentially complete removal of fast inactiv...

MRI research examining structural brain atrophy in Alzheimer’s disease (AD) generally focuses on medial temporal and cortical structures, but amyloid and tau deposits also accumulate in the caudate. Here we mapped the 3D profile of caudate atrophy using a surface mapping approach in subjects with AD and mild cognitive impairment (MCI) to identify potential clinical and pathological correlates. ...