RATIONALE Compound 21 (C-21) is a highly selective nonpeptide angiotensin AT2 receptor (AT2R) agonist. OBJECTIVE To test the hypothesis that chronic AT2R activation with C-21 induces natriuresis via an action at the renal proximal tubule (RPT) and lowers blood pressure (BP) in experimental angiotensin II (Ang II)-dependent hypertension. METHODS AND RESULTS In rats, Ang II infusion increased...

BACKGROUND Residual pleural thickening (RPT) still occurs in most patients with tuberculosis pleurisy despite advances in the treatment of tuberculosis. The aim of this study was to evaluate the significance of RPT in tuberculosis pleurisy with the patients clinical findings, biochemical and microbiological properties of pleural effusion and with the total adenosine deaminase (ADA) and isoenzym...

BACKGROUND treatment of Mycobacterium ulcerans disease, or Buruli ulcer (BU), has shifted from surgery to treatment with streptomycin(STR)+rifampin(RIF) since 2004 based on studies in a mouse model and clinical trials. We tested two entirely oral regimens for BU treatment, rifampin(RIF)+clarithromycin(CLR) and rifapentine(RPT)+clarithromycin(CLR) in the mouse model. METHODOLOGY/PRINCIPAL FIND...

NADPH oxidases are the major sources of reactive oxygen species in cardiovascular, neural, and kidney cells. The NADPH oxidase 5 (NOX5) gene is present in humans but not rodents. Because Nox isoforms in renal proximal tubules (RPTs) are involved in the pathogenesis of hypertension, we tested the hypothesis that NOX5 is differentially expressed in RPT cells from normotensive (NT) and hypertensiv...

In this paper, an effective and reliable skew estimation technique for machine printed documents and photos using radon transform is proposed and is compared with other methods used for skew estimation such as Fast Fourier Transform (FFT), Hough Transform (HT), combination of Horizontal Projection Profile (HPP) and Hough Transform, combination of Gabor filter and Radon transform, combination of...

Motivated by deformation quantization, we consider in this paper -algebras A over rings C = R(i), where R is an ordered ring and i = −1, and study the deformation theory of projective modules over these algebras carrying the additional structure of a (positive) A-valued inner product. For A = C(M), M a manifold, these modules can be identified with Hermitian vector bundles E overM . We show tha...