BACKGROUND Exposomics is the cutting-edge concept of screening the environmental risk factors for disease. In the novel "top-down" approach, we estimate the molecular exposome by measuring all body fluid analytes in a case-controlled study. However, to detect diverse pollutants, a sufficient sample size and multiple analytical methods are required. This may lead to dramatically increased costs ...

For case-control studies that rely on expensive assays for biomarkers, specimen pooling offers a cost-effective and efficient way to estimate individual-level odds ratios. Pooling helps to conserve irreplaceable biospecimens for the future, mitigates limit-of-detection problems, and enables inclusion of individuals who have limited available volumes of biospecimen. Pooling can also allow the st...

In Huang and Weng (2004), Huang and Weng introduced pooling spaces, and constructed pooling designs from a pooling space. In this paper, we introduce the concept of pooling semilattices and prove that a pooling semilattice is a pooling space, then show how to construct pooling designs from a pooling semilattice. Moreover, we give many examples of pooling semilattices and thus obtain the corresp...

The prudent peasant mitigated the risk of crop failures by scattering his arable land throughout his village, Deirdre McCloskey argued, because alternative risksharing institutions did not exist. But, alternatives did exist, this essay concludes. Medieval English peasants formed two types of farmers’ cooperatives. Fraternities protected members from the perils of everyday life. Customary poor l...

For case-control studies that rely on expensive assays for biomarkers, specimen pooling offers a cost-effective and efficient way to estimate individual-level odds ratios. Pooling helps to conserve irreplaceable biospecimens for the future, mitigates limit-of-detection problems, and enables inclusion of individuals who have limited available volumes of biospecimen. Pooling can also allow the st...

After more than 20 years of extensive study, the policy of pooling lead-time risk by simultaneously splitting replenishment orders among several suppliers continues to attract the attention of researchers. A critical review of the extant literature is conducted. Important and persistent limitations of current research are revealed that may make the policy uneconomical, in general, and more prom...

The stochastic location-inventory network design model with risk pooling considers the distribution network design problem in which all the retailers face uncertain demand. The riskpooling benefits can be achieved by allowing some of the retailers to operate as distribution centers (DCs) for other retailers to commit a given service level. The target is to minimize the expected total cost of DC...