The fact that histones are modified by acetylation has been known for almost 30 years. The recent identification of enzymes that regulate histone acetylation has revealed a broader use of this modification than was suspected previously. Acetylases are now known to modify a variety of proteins, including transcription factors, nuclear import factors and alpha-tubulin. Acetylation regulates many ...

The recent rapid growth of the Internet as a medium of communication and commerce, combined with the development of sophisticated software tools, are to a large extent responsible for producing a new kind of information: databases with detailed records about consumers’ preferences. These databases have become part of a Þrm’s assets, and as such they can be sold to competitors. This possibility ...

Some empirically minded philosophers of science argue that the evidence should choose the best theory from among theoretical rivals. However, the evidence may not speak clearly, a problem of ‘underdetermination of theory by data’. We examine this problem in a concrete setting, rival theories of smoking behaviour. We investigate whether several uncontested pieces of empirical evidence allow us t...

We examine how revenue-sharing and profit-sharing stakes affect price competition intensity under duopoly. Our analysis builds on the framework introduced by Varian (1980) accounts for fundamental asymmetries in terms of cost consumer loyalty. A stake exists when a firm appropriates share its rival’s revenues or profits. For example, marketplace owner that charges third-party seller an ad valor...