نتایج جستجو برای: ron arad
تعداد نتایج: 2657 فیلتر نتایج به سال:
Despite the promising results from initial studies, there are significant limitations in the application of MET-targeted therapy in gastric cancer. Intrinsic resistance is one of the major obstacles. The aim of this study is to identify the responsible receptor tyrosine kinases (RTKs) that determine the unresponsiveness of MET inhibitor in MET-positive gastric cancer. through an RNA-interferenc...
Macrophage Stimulating Protein (MSP) is the only known ligand for the receptor tyrosine kinase Ron. The MSP/Ron pathway is involved in several important biological processes, including macrophage activity, wound healing, and epithelial cell behavior. A role for MSP/Ron in breast cancer has recently been elucidated, wherein this pathway regulates tumor growth, angiogenesis, and metastasis. Here,...
RON is a member of the c-MET receptor tyrosine kinase family. Like c-MET, RON is expressed by a variety of epithelial-derived tumors and cancer cell lines and it is thought to play a functional role in tumorigenesis. To date, antagonists of RON activity have not been tested in vivo to validate RON as a potential cancer target. In this report, we used an antibody phage display library to generat...
The tyrosine kinase Ron, receptor for MSP (macrophage-stimulating protein), displays several serine residues of unknown functions. Using [(32)P]H(3)PO(4) metabolic labelling, we found that Ron is serine-phosphorylated and dephosphorylated in vitro by PP1 (protein phosphatase 1). PP1 associates with Ron obtained from cells of different origins. The association is stimulated by MSP or serum and i...
IOANA MIHAELA CITU1, CLAUDIA TOMA2, CRISTINA TRANDAFIRESCU1, DIANA ANTAL1, CSILLA ZAMBORI3, CAMELIA OPREAN1, FLORINA BOJIN1, FLORIN BORCAN1*, VIRGIL PAUNESCU1, VOICHITA LAZUREANU1 1 “Victor Babes” University of Medicine and Pharmacy Timisoara, 2ndEftimieMurgu Sq., Timisoara-300041, Romania 2“VasileGoldis”University, 1stFeleacului Str., Arad-310396, Romania 3 National Institute of Research Devel...
We prove the Arad–Herzog conjecture for various families of finite simple groups — if A and B are nontrivial conjugacy classes, then AB is not a conjugacy class. We also prove that if G is a finite simple group of Lie type and A and B are nontrivial conjugacy classes, either both semisimple or both unipotent, then AB is not a conjugacy class. We also prove a strong version of the Arad–Herzog co...
Aims. To describe the baseline characteristics of an Australian population-based cohort of rheumatoid arthritis (RA) patients commencing biological therapy. Methods. Descriptive analysis from the Australian Rheumatology Association Database (ARAD). Results. Up to October 2006, there were 681 RA patients taking biologics enrolled in ARAD. Baseline data were available for 624 (72% female, mean (S...
The recepteur d'origine nantais (RON) receptor tyrosine kinase is highly expressed in various cancers including human hepatocellular carcinoma (HCC) and involved in tumor progression. The aims of the current study were to evaluate whether RON affects tumor cell behavior and oncogenic signaling cascades in HCC cells. We investigated the biologic role of RON on tumor cell behavior and oncogenic s...
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