نتایج جستجو برای: rora
تعداد نتایج: 204 فیلتر نتایج به سال:
Abstract Background The human circadian clock is present in cells throughout the body. It consists of CLOCK and BMAL1 that heterodimerize bind to E-box sequences mediate transcription a large number genes, including Periods (PERs) Cryptochromes (CRYs). PERs CRYs constitute part negative feedback loop inhibit CLOCK:BMAL1-mediated transcription. Recently, we have shown patients with active ulcera...
Effects of parental genotype or parent-offspring genetic interaction are well established in model organisms for a variety of traits. However, these transgenerational genetic models are rarely studied in humans. We have utilized an autism case-control study with 735 mother-child pairs to perform genome-wide screening for maternal genetic effects and maternal-offspring genetic interaction. We us...
Egr2 and 3 are important for maintaining immune homeostasis. Here we define a fundamental function of Egr2 and 3 operating as a checkpoint that controls the transition between clonal expansion and differentiation of effector T cells. Egr2 and 3 deficiency resulted in defective clonal expansion but hyperactivation and excessive differentiation of T cells in response to viral infection. Conversel...
Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers. We have discovered novel loci affecting GGT in a genome-wide association study (rs1497406 in an intergenic region of chromosome 1, P = 3.9 × 10(-8); rs944002 in C14orf73 on chromosome 14, P ...
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