sperm is particularly susceptible to reactive oxygen species (ros) during critical phases of spermiogenesis. however, the level of seminal ros is restricted by seminal antioxidants which have beneficial effects on sperm parameters and developmental potentials. mitochondria and sperm plasma membrane are two major sites of ros generation in sperm cells. besides, leukocytes including polymer phonu...

The involvement of reactive oxygen species (ROS) in regulating vascular function both in normal vessels and as part of an adaptive response during disease has been intensively studied. From the recognition that ROS serve as important signaling molecules has emerged multiple lines of evidence that there is a functional connectivity between intracellular sites of ROS production. This cross talk h...

Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two main reasons for poor outcomes of treatment. Pyroptosis is a newly discovered form programmed cell death, featuring surprising proinflammatory activity. Recent evidence shows that pyroptosis leads strong inflammatory responses significant regression, which different from apoptotic death. Strategies based on t...

isolated rat hepatocytes in culture were incubated with different concentrations of iron-sorbitol (50, 100, 150, and 200 µm) to assess the changes in reactive oxygen species (ros) and lipid peroxidation leading to apoptotic hepatocyte cell death. the viability of hepatocytes was declined depending on the iron concentration. one hour incubation of the cells with 100 µm iron resulted in decreased...

Cancer Therapy In article number 2202694, Dong-Hyun Kim and co-workers develop reactive oxygen species (ROS)–responsive biodegradable metallic nanoparticles that can be used for various biomedical applications. Given the challenges of non-biodegradability potent inorganic nanoparticles, introduction a ROS-responsive cleavable hierarchical supra-nanostructure provides an exciting opportunity ROS...

reactive oxygen species (ros) are produced in many normal and abnormal processes in humans, including atheroma, asthma, joint diseases, cancer, and aging. basal levels of ros production  in  cells  could  be  related  to  several  physiological functions  including  cell proliferation, apoptosis and homeostasis. however, excessive ros production above basal levels would impair and oxidize dna, ...

background: excess reactive oxygen species (ros) in the semen is believed to affect fertility in men. morphologically abnormal sperms and their relation to seminal oxidative stress in infertile and subfertile men are not clear. objective: to correlate various sperm morphological defects with seminal oxidative stress in infertile and subfertile men. materials and methods: the study included 25 p...

Front Cover: Chronic wound generates high levels of reactive oxygen species (ROS), which inhibits normal healing process. In article number 2200234, Justin J. Chung and co-workers fabricate ROS suppressive antioxidant hydrogel by chemically cross-linking kraft lignin with gelatin. The flexible lignin-gelatin is able to suppress ROS, exhibit antibacterial activity.

background: therapeutic potential of in vitro maturation (ivm) in infertility is growing with great promise. although significant progress is obtained in recent years, existing ivm protocols are far from favorable results. the first aim of this study was to investigate whether two step ivm manner change reactive oxygen species (ros) and total antioxidant capacity (tac) levels. the second aim wa...

Background: Diabetes mellitus (DM) is characterized by the presence of hyperglycemia. It has been documented that oxidative stress and reactive oxygen species (ROS) production have a key role in the pathogenesis of diabetes and its complications. Neutrophils as a part of immune system produce ROS, neutrophils function might be altered in diabetes. Lamium album is known to have antioxidant, and ...