S ince the 1950s, rotavirus has been recognized in veterinary circles as an important cause of diarrhoea in young livestock and poultry. In the 1970s, the virus was found to be a cause of infantile diarrhoea in humans [1], and after this discovery rotavirus rapidly became established as the most prevalent cause of paediatric diarrhoea [2]. Rotavirus preferentially infects the mature villous ent...

BACKGROUND Antigenemia is commonly detected in rotavirus-infected children. Although rotavirus RNA has been detected in serum, definitive proof of rotavirus viremia has not been shown. We aimed to analyze a defined patient population to determine if infectious virus could be detected in sera from children with rotavirus antigenemia. METHODS AND FINDINGS Serum samples obtained upon hospitaliza...

Rotavirus infection is the most common cause of severe dehydrating gastroenteritis in infants and young children and remains a significant clinical problem worldwide. The severity and the burden of rotavirus disease could be reduced through the implementation of an effective vaccine. The aim of this study was to characterize rotavirus strains circulating in the local community as part of an ong...

Rotavirus infection is one of the primary causes of acute gastroenteritis in industrialized countries and may be a cause of severe disease in children. Here we present the results of analysis of specific indicators which characterize the burden of rotavirus infection in Russia such as passive surveillance data for rotavirus gastroenteritis cases (RG), the proportion of outbreaks of rotavirus pe...

Rotavirus remains the number one cause of severe diarrhea in children aged 5 years in the United States and worldwide. Each year in the United States, rotavirus is responsible for approximately 600,000 outpatient medical visits, 55 to 70,000 hospitalizations, and 20 to 60 deaths. Disease caused by rotavirus is extremely common as almost every child is infected in the first 5 years of life. Rota...

That rotavirus infection can cause neurological symptoms in young children has been well established. However, it is surprising why rotavirus infection has been overlooked as a cause of neonatal seizures for many years, despite significant research interest in neonatal rotavirus infection. Neonates are the age group most vulnerable to seizures, which are typically attributed to a wide range of ...

In order to determine the sensitivity and reliability of antirotaviral fecal immunoglobulin A (IgA) as an indicator of rotavirus reinfection, the antibody responses to rotavirus of 44 infants with severe rotavirus gastroenteritis recruited on admission to a hospital were studied. Feces were collected daily during hospitalization and weekly thereafter, and sera were obtained every 4 months, for ...

Rotavirus-neutralizing antibody responses in sera and stools of children hospitalized with rotavirus gastroenteritis and then monitored longitudinally were optimally detected by using local rotavirus strains. Stool responses were highest on days 5 to 8 after the onset of diarrhea. Longitudinal monitoring suggested that serum neutralizing antibody responses were a more useful measure of severely...

background rotaviruses are the most common cause of viral gastroenteritis in newborns and young children. the current study intended to investigate the presence of rotavirus antigen in fecal specimens of children with acute diarrhea, to determine its prevalence and to examine its distribution pattern by age, gender and season. objectives this was a retrospective investigation of cases with rota...

Rotavirus gastroenteritis is a major health problem among Malawian children. Studies spanning 20 years have described the importance, epidemiology and viral characteristics of rotavirus infections in the country. Despite a wide diversity of circulating rotavirus strains causing severe disease in young infants, a clinical trial of a human rotavirus vaccine clearly demonstrated the potential for ...