IntroductionThe aim of this study was to determine the utility different methods predict rapid progressors (RPs) and their clinical characteristics in Asia-Pacific patients with autosomal dominant polycystic kidney disease (ADPKD).MethodsThis a multinational retrospective observational cohort ADPKD region. Five hospitals from Australia, China, South Korea, Taiwan Turkey participated study. RP d...

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. The cost of his treatment requires a large amount money. This study aims to analyze cost-effectiveness drug use in hospitalized patients with category non-comorbid suspects combination antiviral and antibiotic therapy at Bandung Hospital Period July – December 2021. uses non-analytic descriptive method. Data collection was carrie...

A new study by Sennino and colleagues demonstrates that selective VEGF inhibition via the use of an anti-VEGF antibody is sufficient to increase invasion and metastasis in a c-Met-dependent manner. Anti-VEGF therapy induced tumor hypoxia, hypoxia-inducible factor 1α, and c-Met activation in the RIP-Tag2 model of neuroendocrine pancreatic cancer. Selective c-Met inhibition was sufficient to bloc...

BACKGROUND Patient medication adherence is multidimensional and poses significant concerns to health care professionals. One aspect of adherence is a patient forgetting to take their prescribed medication, which may be improved with reminder packaging (RP). The objective of this analysis was to assess the impact of RP on patient adherence to antihypertensive therapy. METHODS This retrospectiv...

BACKGROUND AND PURPOSE The purpose of the study is to study the nerve conductivity of the tibial motor, peroneal motor, peroneal sensory, and sural nerves in patients with primary and secondary Raynaud's phenomenon (RP). SUBJECTS Twenty each: primary RP, secondary RP, and normal controls. METHODS Electromyography using distal latency (DL) and nerve conduction velocity (NCV) as dependent var...

A simple, sensitive, precise, accurate, and robust, high-performance liquid chromatographic method has been developed to simultaneously estimate Metformin (MET) Dapagliflozin (DAPA) in pharmaceutical formulation. Design of experiments (DoE) was applied for multivariate optimization the experimental conditions RP-HPLC method. risk assessment performed identify critical parameters. The mobile pha...

recently, as the result of the development in modern imaging, computerized three dimensional data processing and advanced engineering techniques, an prosthesis that match the skeletal anatomy can be accurately designed from computer aided design (cad) technique and the physical model of prosthesis or skull replica can be produced through rapid prototyping (rp), rapid tooling (rt), and computer ...

Many studies have revealed molecular connections between breast and bone. Genes, important in the control of bone remodeling, such as receptor activator of nuclear kappa (RANK), receptor activator of nuclear kappa ligand (RANKL), vitamin D, bone sialoprotein (BSP), osteopontin (OPN), and calcitonin, are expressed in breast cancer and lactating breast. Epithelial-mesenchymal transition (EMT) and...

Simple, accurate and precise Zero order, first derivative spectrophotometric and chromatographic methods have been developed and validated for the determination of linagliptin (LNG) and metformin HCl (MET). The zero order and first derivative spectrophotometric methods were used for the determination of LNG in the range of 5-30 μg mL(-1) by measuring the absorbance at 299 nm and 311 respectivel...