BACKGROUND A single oral dose of cyclosporin-A (CsA) transiently reduces renal plasma flow (RPF) and glomerular filtration rate (GFR) in transplant patients and, in some patients, chronic administration of CsA leads to renal impairment and fibrosis. Based on experimental studies, several mediators including free radicals have been proposed to account for CsA-nephrotoxicity. We have previously r...

The objective of this study was to determine the effects of grasp conditions (types of grasp, grasp width, glove and types of coupling) on maximal pushing force (MPF) and required pinch force (RPF) during snap fit assembly. The results indicated that the type of grasp, the type of coupling and wearing gloves have significant (p<0.05) effects on both MPF and RPF. Regarding the pair wise comparis...

Early diagnosis and treatment of under-recognized retroperitoneal fibrosis (RPF) are essential before reaching the poorly responsive fibrotic stage. Although most patients respond to medical therapy, relapses common. Open surgery in medically resistant is associated with major adverse clinical events. Therefore, we aim compare outcomes endovascular repair RPF who were refractory optimal managem...

Aging and abnormal aldosterone regulation are both associated with vascular disease. We hypothesized that aldosterone dysregulation influences the age-related risk of renal vascular and cardiovascular disease. We conducted an analysis of 562 subjects who underwent detailed investigations under conditions of liberal and restricted dietary sodium intake (1124 visits) in the General Clinical Resea...

Resuscitation-promoting factor (Rpf) is a protein that has been found in a number of different Actinobacteria species and has been shown to promote the growth of active cells and resuscitate dormant (non-dividing) cells. We previously reported the biological activity of an Rpf protein in Tomitella biformata AHU 1821(T), an Actinobacteria isolated from a permafrost ice wedge. This protein is exc...

BACKGROUND According to experimental data, the afferent glomerular arteriole is particularly under control of nitric oxide (NO). By use of pharmacological manoeuvres, we examined whether this finding holds true in the human renal circulation in vivo. METHODS Seventy-seven volunteers (aged 50+/-9 years) with mild to moderate essential hypertension (n = 57) or arterial normotension (n = 20) wer...

We report the successful application of a simple recursive proportional-feedback (RPF) algorithm to control chemical chaos observed during the electrodissolution of a rotating copper disk in a sodium acetate/acetic acid buffer. The RPF method is generally applicable to the control of chaotic systems that are highly dissipative and adequately described by one-dimensional maps of a single variabl...

Very little is known about the culturability and viability of mycobacteria following their phagocytosis by macrophages. We therefore studied populations of the avirulent 'Academia' strain of Mycobacterium tuberculosis isolated from murine peritoneal macrophage lysates several days post-infection in vivo. The resulting bacterial suspensions contained a range of morphological types including rods...

OBJECTIVE One of the earliest signs of vascular change is endothelial dysfunction, which is also known to provoke albuminuria and to predict cardiovascular prognosis. The aim of this study was to analyze the effects of renin-angiotensin system (RAS) blockade on renal endothelial function. RESEARCH DESIGN AND METHODS In a multicenter, prospective, double-blind, forced-titration, randomized stu...

Extracellular fluid volume (ECF), plasma volume (PV), glomerular filtration rate (GFR), renal plasma flow (RPF), efferent arteriolar oncotic pressure (pi E), sodium output (UNaV), and sodium clearance (CNa) were determined in 150 men including 50 normal controls (NC) and 100 sustained essential hypertensive patients (EH). Total effective vascular compliance (TEVC) and central venous pressure (C...