Tumour metastasis suppressors are inhibitors of metastasis but their mechanisms of action are generally not understood. We previously showed that the suppressor Raf kinase inhibitory protein (RKIP) inhibits breast tumour metastasis in part via let-7. Here, we demonstrate an integrated approach combining statistical analysis of breast tumour gene expression data and experimental validation to ex...

Rangelands provide significant socioeconomic and environmental benefits to humans. However, climate variability anthropogenic drivers can negatively impact rangeland productivity. The main goal of this study was investigate structural productivity changes in ecosystems New Mexico (NM), the southwestern United States America during 1984–2015 period. This achieved by applying time series segmente...

A new, general approach is described for approximate inference in first-order probabilistic languages, using Markov chain Monte Carlo (MCMC) techniques in the space of concrete possible worlds underlying any given knowledge base. The simplicity of the approach and its lazy construction of possible worlds make it possible to consider quite expressive languages. In particular, we consider two ext...

Analysis of this air induction system testing aims to analyze the on Daihatsu Xenia types XI in 2011. The research uses descriptive methods by and analyzing Type Mobils 2011 using EFI X 431 Pro multitester scanner obtain data. test results show that: 1. sensor map is good condition because voltage produced ? 3.5 V - 4 is: 3.7 V. 2. poor resistance 2.21 k ohm 2,69 K Ohm, namely: 1.74 KOHM. 3. IS...

The addition of racing exhaust to a vehicle will greatly affect the quality emissions. Racing exhausts that use FreeFlow system which throws remaining combustion gases out immediately without any deflection and catalyst in exhaust. DB Killer uses nest-shaped copper material, besides reducing noise it also reduces excessive emissions material is easy obtain, inexpensive, has simple manufacturing...

The properties of nuclei far from stability provide a stringent test of the validity of shell model Hamiltonians derived from data for nuclei near the valley of stability. Failure of shell model calculations to extrapolate to nuclei far from stability may indicate a breakdown of symmetries assumed in the model. Such a breakdown may provide evidence for new regions of deformation as were found f...